MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile

WH Mahallawi, OF Khabour, Q Zhang, HM Makhdoum… - Cytokine, 2018 - Elsevier
2, IL-4, IL-5, IL-13, and TGF-α (P > .05). Our results demonstrate a marked pro-inflammatory
cytokine … of airway epithelial cell lines with MERS-CoV induced the expression of IFN-α2, IFN-…

Attenuated interferon and proinflammatory response in SARS-CoV-2–infected human dendritic cells is associated with viral antagonism of STAT1 phosphorylation

D Yang, H Chu, Y Hou, Y Chai, H Shuai… - The Journal of …, 2020 - academic.oup.com
expression of proinflammatory cytokines and chemokines was not substantially triggered by
SARS-CoV-2 … among the 8 representative cytokine/chemokine evaluated, SARS-CoV-2 only …

Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines

A Fara, Z Mitrev, RA Rosalia, BM Assas - Open biology, 2020 - royalsocietypublishing.org
… prominent cytokine families and their potential role in COVID-19, the type I and II interferons,
… most affected are those with high ACE2 expression, the entry receptor for SARS-Cov-2. …

Does high cardiorespiratory fitness confer some protection against proinflammatory responses after infection by SARSCoV2?

H Zbinden‐Foncea, M Francaux, L Deldicque… - …, 2020 - Wiley Online Library
… tissues and organs that have a high expression of angiotensin converting enzyme 2 (ACE2).
As a … the levels of proinflammatory cytokines are increased in patients with COVID-19 is not …

Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19

SA Lowery, A Sariol, S Perlman - Cell Host & Microbe, 2021 - cell.com
SARS-CoV-2-encoded proteins (red) inhibit multiple aspects of these pathways, resulting
in decreased IFN and altered proinflammatory cytokine expression. Many of the SARS-CoV-2

… adapted SARS-CoV in a mouse cell line stably expressing the murine SARS-CoV receptor mACE2 efficiently induces the expression of proinflammatory cytokines

JA Regla-Nava, JM Jimenez-Guardeño… - Journal of virological …, 2013 - Elsevier
… In this work, efficiently transfectable mouse cell lines stably expressing the murine SARS-CoV
receptor angiotensin converting enzyme 2 (ACE2) have been generated. These cells …

Could SARS-CoV-2-induced hyperinflammation magnify the severity of coronavirus disease (CoViD-19) leading to acute respiratory distress syndrome?

ASS Girija, EM Shankar, M Larsson - Frontiers in immunology, 2020 - frontiersin.org
… storm) characterized by exaggerated levels of pro-inflammatory cytokines and other …
Gender-based variations in the expression of ACE2 could likely have implications in severe …

Liu Shen capsule shows antiviral and anti-inflammatory abilities against novel coronavirus SARS-CoV-2 via suppression of NF-κB signaling pathway

Q Ma, W Pan, R Li, B Liu, C Li, Y Xie, Z Wang… - Pharmacological …, 2020 - Elsevier
… could markedly decrease pro-inflammatory cytokine expression in … of the inhibition of LS
against SARS-CoV-2 infection. … upregulated proinflammatory cytokines induced by SARS-CoV-2

Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications …

SKP Lau, CCY Lau, KH Chan… - Journal of General …, 2013 - microbiologyresearch.org
… six cytokines assayed using ELISA, only two, IL-… proinflammatory cytokine induction by
MERS-CoV. In this study, analysis of cytokine mRNA expression in Calu-3 cells infected by MERS-…

Relative expression of proinflammatory molecules in COVID19 patients who manifested disease severities

S Nigar, SMT Shah, MAA Setu, SD Dip… - Journal of medical …, 2021 - Wiley Online Library
… We performed SYBRgreen intercalation qRT-PCR to detect the expression level of two
proinflammatory cytokines (TNF-α and IL-6), two antiviral cytokines (IFN-γ and IL-12), four …