[HTML][HTML] Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges

FEM Ali, ZM Mohammedsaleh, MM Ali… - World journal of …, 2021 - ncbi.nlm.nih.gov
… -converting enzyme 2 (ACE2) receptor expression or cytokine storm strength production.
In a … with the release of many pro-inflammatory cytokines responsible for critical illness[43,44]. …

Up-regulation of IL-6 and TNF-α induced by SARS-coronavirus spike protein in murine macrophages via NF-κB pathway

W Wang, L Ye, L Ye, B Li, B Gao, Y Zeng, L Kong… - Virus research, 2007 - Elsevier
… protein of SARS to modulate the proinflammatory cytokines (IL-6, … To investigate whether S
protein can induce cytokine expression2E). These results demonstrate that the recombinant …

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly decimates human spleens and lymph nodes

Z Feng, B Diao, R Wang, G Wang, C Wang, Y Tan… - MedRxiv, 2020 - medrxiv.org
… apoptosis and proinflammatory cytokine expression were … We here showed that the
expression of SARS-CoV-2 receptor … SARS-CoV-2 is a cytopathic virus which can directly induce …

[HTML][HTML] SARS-CoV-2 Delta spike protein enhances the viral fusogenicity and inflammatory cytokine production

Z Ao, MJ Ouyang, TA Olukitibi, X Yao - Iscience, 2022 - cell.com
proinflammatory cytokine, such as TNF-α, IL-1β, and IL-6, released from human macrophages
and dendritic cells. Overall, these studies provide evidence to support the important role of …

Role of SARS-CoV-2-induced cytokines and growth factors in coagulopathy and thromboembolism

F Ahmad, M Kannan, AW Ansari - Cytokine & Growth Factor Reviews, 2022 - Elsevier
… As observed in SARS-CoV-1 infection, the expression levels of cytokine IL-1β, … Among
the proinflammatory cytokines, IL-6 has been identified as the most common and predominant …

A proteomic perspective and involvement of cytokines in SARS-CoV-2 infection

S Banu, R Nagaraj, MM Idris - Plos one, 2023 - journals.plos.org
… In this paper, we described the effect of SARS-CoV-2 infection in patients on the expression
… Our study found that pro-inflammatory cytokines such as IL-1, IL-6, IL-10, and TNF- α, as well …

Type I and III interferon responses in SARS-CoV-2 infection

YM Kim, EC Shin - Experimental & molecular medicine, 2021 - nature.com
… In general, type I IFNs trigger faster and stronger ISG induction than type III IFNs and promote
the additional expression of proinflammatory cytokines and chemokines, which may cause …

SARS-CoV-2 Spike S1 glycoprotein is a TLR4 agonist, upregulates ACE2 expression and induces pro-inflammatory M1 macrophage polarisation

MM Aboudounya, MR Holt, RJ Heads - BioRxiv, 2021 - biorxiv.org
… the secretion of pro-inflammatory cytokines and chemokines … secretion of pro-inflammatory
cytokines and chemokines; (ii) an … I interferons and some anti-inflammatory cytokines (see [1] …

SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
… Patients with COVID-19 with hypoxic respiratory failure have … of pro-inflammatory cytokines,
such as interleukin-1 (IL-1), IL-6, … PAI1 expression is highly increased in COVID-19, and high …

Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients

J Liu, S Li, J Liu, B Liang, X Wang, H Wang, W Li… - …, 2020 - thelancet.com
… lymphopenia and a proinflammatory cytokine storm is higher in severe COVID-19 patients
than … may serve as a useful prognostic factor for early identification of severe COVID-19 cases. …