SARS-CoV-2 early infection signature identified potential key infection mechanisms and drug targets

Y Li, A Duche, MR Sayer, D Roosan, FG Khalafalla… - BMC genomics, 2021 - Springer
… to SARS-CoV-2 infection by generating a gene expression signature, … proinflammatory
cytokine IL-33 [28, 45]. In addition to IL-33, P2Y 2 R mediates the production of several cytokines

SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

S Khan, MS Shafiei, C Longoria, JW Schoggins… - Elife, 2021 - elifesciences.org
… the induction of proinflammatory cytokines and chemokines during SARS- CoV- 2 infection is
… The expression of inflammatory cytokines and chemokines was measured by real- time RT- …

SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation

S Li, Y Zhang, Z Guan, H Li, M Ye, X Chen… - Signal transduction and …, 2020 - nature.com
… -8 can induce the expression of pro-inflammatory cytokines and process pro-IL-1β and IL-18
in the same way as caspase-1, resulting in the release of bioactive cytokines, through either …

[HTML][HTML] … and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease: Running title: Propolis against SARS-CoV-2 infection and COVID-19

AA Berretta, MAD Silveira, JMC Capcha… - Biomedicine & …, 2020 - Elsevier
SARS-CoV-2 infection is associated with increased levels of chemokines and activated
pro-inflammatory cytokines … caused by SARS-CoV-2, such as reducing TMPRSS2 expression, …

Emerging aspects of cytokine storm in COVID-19: The role of proinflammatory cytokines and therapeutic prospects

R Dharra, AK Sharma, S Datta - Cytokine, 2023 - Elsevier
SARS-CoV-2 mediated cytokine storm is associated with the mortality and morbidity of COVID-19
… However, deviation in the IFN-γ expression is related to several autoimmune and auto-…

SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression

R Cecchini, AL Cecchini - Medical hypotheses, 2020 - Elsevier
pro-inflammatory cytokine inhibitors and anticoagulants could help the recovery of patients
with COVID-19… involved in the expression of cytokines and Nrf2 activation, responsible for the …

Novel signaling pathways regulate SARS-CoV and SARS-CoV-2 infectious disease

LC Cheng, TJ Kao, NN Phan, CC Chiao, MC Yen… - Medicine, 2021 - journals.lww.com
… that several cytokine genes were up-regulated after SARS-CoV-2 … in gene expressions
between SARS-CoV-2- and SARS-CoV-… gene expression profiles in SARS-CoV-/SARS-CoV-2-…

… of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic …

A Jafarzadeh, P Chauhan, B Saha, S Jafarzadeh… - Life sciences, 2020 - Elsevier
… The SARS-CoV-2-infected monocytes and macrophages can … numerous types of pro-inflammatory
cytokines and chemokines… SARS-CoV-2-derived ORF3b suppresses the expression of …

Exacerbated innate host response to SARS-CoV in aged non-human primates

SL Smits, A De Lang, JMA Van Den Brand… - PLoS …, 2010 - journals.plos.org
… and diminishes pro-inflammatory gene expression, including … that higher amounts of
pro-inflammatory cytokines, such as IL-… treatment of SARS-CoV-infected aged mice with type II

The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm

M Hamdorf, T Imhof, B Bailey-Elkin… - Journal of Molecular …, 2024 - academic.oup.com
cytokine and chemokine expressionpro-inflammatory cytokines and chemokines, including
IL-10. The observed ORF8-induced cytokine profile showed close similarities with COVID-19