SARS-CoV-2 Nsp2 contributes to inflammation by activating NF-κB

É Lacasse, L Gudimard, I Dubuc, A Gravel, I Allaeys… - Viruses, 2023 - mdpi.com
… of mice with SARS-CoV-2 induces the expression of several pro-inflammatory CC and CXC
… than other pro-inflammatory cytokines and type I IFN (Figure 1D). These results show that …

The comparative immunological characteristics of SARS-CoV, MERS-CoV, and SARS-CoV-2 coronavirus infections

Y Zhang, B Li, B Ning - Frontiers in Immunology, 2020 - frontiersin.org
… The pro-inflammatory cytokines IL-8, TNF-α, and IL-6 induce migration and recruitment of …
-specific CD4+ and CD8+ T cell responses and cytokine expression in MERS patients who had …

T‐cell responses and therapies against SARSCoV2 infection

SM Toor, R Saleh, V Sasidharan Nair, RZ Taha… - …, 2021 - Wiley Online Library
SARS-CoV-2-infected pneumocytes and alveolar macrophages prompted the release of
proinflammatory cytokines … + T cells of SARS-CoV-2 patients have higher expression of NK cell …

An update on innate immune responses during SARS-CoV-2 infection

Y Zhang, S Chen, Y Jin, W Ji, W Zhang, G Duan - Viruses, 2021 - mdpi.com
proinflammatory cytokines in response to SARS-CoV-2 … mechanism for SARS-CoV-2
immune evasion (see Table 1). … induces the abnormal expression of proinflammatory factors, …

Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: possible relevance to pathogenesis

CY Cheung, LLM Poon, IHY Ng, W Luk, SF Sia… - Journal of …, 2005 - Am Soc Microbiol
… to infections with the SARS coronavirus (SARS-CoV) and other … SARS-CoV nucleoprotein
expression in SARS-CoV-infected … expression when infected at an MOI of 1 to 2 (Fig. …

SARS-CoV-2 spike protein activates human lung macrophages

F Palestra, R Poto, R Ciardi, G Opromolla… - International Journal of …, 2023 - mdpi.com
… and expression of several cytokines and chemokines by HLMs and the expression of
ACE2 … to spike protein release pro-inflammatory cytokines, including TNF-α, IL-1β, IL-6, and …

Role of the immune microenvironment in SARS-CoV-2 infection

CH Ye, WL Hsu, GR Peng, WC Yu, WC Lin… - Cell …, 2021 - journals.sagepub.com
… Focusing on SARS-CoV-2, studies have observed that this virus can … release of proinflammatory
cytokines contribute to major … , the SARS-CoV-2 virus infects cells via expression of the …

… cytokines in COVID-19 patients: A review on molecular mechanisms, immune functions, immunopathology and immunomodulatory drugs to counter cytokine storm

AA Rabaan, SH Al-Ahmed, J Muhammad, A Khan… - Vaccines, 2021 - mdpi.com
COVID-19 syndrome is characterized by the uncontrolled and elevated release of pro-inflammatory
cytokines and … , the key terms searched include coronavirus, SARS-CoV-2, COVID

SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

P Pan, M Shen, Z Yu, W Ge, K Chen, M Tian… - Nature …, 2021 - nature.com
… Here we show that SARS-CoV-2 N protein induces proinflammatory cytokines through … In
this work, we found that SARS-CoV-2 N protein could promote the expression of inflammatory …

Nucleopore traffic is hindered by SARS-CoV-2 ORF6 protein to efficiently suppress IFN-β and IL-6 secretion

G Gori Savellini, G Anichini, C Gandolfo, MG Cusi - Viruses, 2022 - mdpi.com
pro-inflammatory cytokines have been reported during infection by the novel SARS-CoV-2
virus… In the present study, we demonstrated that the SARS-CoV-2 ORF6 expression