Proinflammatory cytokines in the olfactory mucosa result in COVID-19 induced anosmia

A Torabi, E Mohammadbagheri… - ACS chemical …, 2020 - ACS Publications
… The primary objective of this study was to explore local proinflammatory cytokine levels in …
Elevated levels of the proinflammatory cytokine TNF-α were seen in the olfactory epithelium …

Mechanism of anosmia caused by symptoms of COVID-19 and emerging treatments

R Najafloo, J Majidi, A Asghari… - ACS Chemical …, 2021 - ACS Publications
… The binding between the virus and these cells causes cytokine release and promotes OE
inflammation (Figure 2). Torabi et al. investigated levels of local pro-inflammatory cytokines in …

[HTML][HTML] Potential mechanisms for COVID-19 induced anosmia and dysgeusia

AA Eshraghi, M Mirsaeidi, C Davies, FF Telischi… - Frontiers in …, 2020 - frontiersin.org
… Since the severity of COVID-19 infection is proportional to levels of these pro-inflammatory
cytokines, the quality and severity of dysgeusia may help in identifying mild, moderate, and …

Anosmia in COVID-19: a bumpy road to establishing a cellular mechanism

K Bilinska, R Butowt - ACS chemical neuroscience, 2020 - ACS Publications
… of proinflammatory cytokines after … as induces the production of proinflammatory cytokines.
Thus, a local innate immune response may also participate in the process leading to anosmia

[HTML][HTML] Management of anosmia in COVID-19: a comprehensive review

K Khurana, CV Singh - Cureus, 2022 - ncbi.nlm.nih.gov
… In the olfactory epithelium, concentrations of local pro-inflammatory cytokines were … The
most plausible causes of the SARS-CoV-2-induced anosmia among the proposed processes are …

Anosmia in COVID-19: mechanisms and significance

AY Han, L Mukdad, JL Long, IA Lopez - Chemical senses, 2020 - academic.oup.com
… The global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute …
onset of anosmia without rhinitis. We aim to review the pathophysiology of anosmia related to …

COVID-19 and anosmia: the story so far

X Meng, Y Pan - Ear, Nose & Throat Journal, 2024 - journals.sagepub.com
… -19-induced anosmia to increase awareness of the condition. … pro-inflammatory cytokine
TNF-α was found. A prospective study has shown that patients with COVID-19-induced anosmia

[HTML][HTML] COVID-19-related anosmia: the olfactory pathway hypothesis and early intervention

A Gori, F Leone, L Loffredo, BL Cinicola… - Frontiers in …, 2020 - frontiersin.org
… stimuli are processed and integrated, suggesting that anosmia is, in some cases, caused
by a central injury mechanism (25). Virally induced damage of OB and other brain areas was …

Relationship between disease severity and serum IL-6 levels in COVID-19 anosmia

DET Sanli, A Altundag, SG Kandemirli… - American journal of …, 2021 - Elsevier
… strong pro-inflammatory molecule and can inducecytokine storm in COVID-19 anosmia
which leads to mucosal, epithelial and receptor damage mediated via proinflammatory cytokines

Anosmia in COVID-19: underlying mechanisms and assessment of an olfactory route to brain infection

R Butowt, CS von Bartheld - The Neuroscientist, 2021 - journals.sagepub.com
… We review recent progress in defining underlying cellular and molecular mechanisms of the
virus-induced anosmia, with a focus on the emerging crucial role of sustentacular cells in the …