Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo

A Schäfer, F Muecksch, JCC Lorenzi, SR Leist… - Journal of Experimental …, 2020 - rupress.org
… In addition to the traditional antibody Fc-effector functions (ie, … Thus, the Fc-mediated effector
functions of neutralizing … , effector function, and antibody combinations on protection from …

Beyond binding: antibody effector functions in infectious diseases

LL Lu, TJ Suscovich, SM Fortune, G Alter - Nature Reviews Immunology, 2018 - nature.com
effector functions contribute to the balance between microbial clearance and pathology and
discuss tractable lessons that may guide rational vaccine and therapeutic … confer protection, …

[HTML][HTML] Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

ES Winkler, P Gilchuk, J Yu, AL Bailey, RE Chen… - Cell, 2021 - cell.com
protection of neutralizing human monoclonal antibodies (mAbs) in SARS-CoV-2-infected
animals. Whereas Fc effector functions … required for optimal protection as therapy. When given …

[PDF][PDF] The effector functions of immunoglobulins: implications for therapy

ES VV3rd, V Ghetie - Therapeutic Immunology, 1995 - docs.wardoberlab.com
… Immunization of the mother can be used to protect the offspring against infectious disease,
as … This procedure has been applied in the clinic to protect new-born infants (especially pre-…

Targeting Fc effector function in vaccine design

SI Richardson, PL Moore - Expert Opinion on Therapeutic Targets, 2021 - Taylor & Francis
effector functions in disease control and protection in viral, bacterial and parasitic infectious
diseases. We review Fc effector function … these functions as part of a robust vaccine strategy. …

Building a better antibody through the Fc: advances and challenges in harnessing antibody Fc effector functions for antiviral protection

BM Gunn, S Bai - Human vaccines & immunotherapeutics, 2021 - Taylor & Francis
effector functions underlie efficacy of many therapeutic antibodies. Left to right: antibodies are
ordered by protection in … activity and low levels of effector functions are less protective than …

[HTML][HTML] Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection

A Zhang, HD Stacey, MR D'Agostino, Y Tugg… - Nature Reviews …, 2023 - nature.com
… relevance of non-neutralizing antibody effector functions in protection against COVID-19, …
-dependent effector functions was essential for the efficacy of monoclonal antibody therapy in …

Effector functions of antibody and CD8+ cells in resolution of rotavirus infection and protection against reinfection in mice

MM MCNEAL, KS Barone, MN RAE, RL WARD - Virology, 1995 - Elsevier
… mice was in B cell development, these results imply that B cell effector function, presumably
… and produced no functional antibody quired for protection against rotavirus reinfection. If pro…

[HTML][HTML] A role for Fc function in therapeutic monoclonal antibody-mediated protection against Ebola virus

BM Gunn, WH Yu, MM Karim, JM Brannan… - Cell host & …, 2018 - cell.com
… These data suggest that Fc-mediated effector functions are key to the protection conferred
by these non-neutralizing mAbs. Moreover, recent data argue that the Fc-domain can augment …

Tc1 and Tc2 effector cell therapy elicit long-term tumor immunity by contrasting mechanisms that result in complementary endogenous type 1 antitumor responses

MJ Dobrzanski, JB Reome, JA Hollenbaugh… - The Journal of …, 2004 - journals.aai.org
… after therapy, protection by Tc2 and Tc1 effector cells were dependent in part on effector cell-…
All mice initially receiving effector cell therapy exhibited protection and long-term survival for …