… proteins or affects a broad array of virus-interacting proteins is unknown. Here, we analyze
adaptation in ~1300 virus-interacting proteins manually curated from a set of 9900 proteins …

… protein functional classes, with genes encoding for protein biosynthesis and degradation
signaling exhibiting the fastest rates of protein adaptation. … variants driving protein adaptive …

… The proteostasis network is a driver of evolvability, facilitating both adaptation and natural
selection by closely managing the link between the phenotype and the genotype to insure …

… The degree to which adaptation in recent human evolution shapes genetic variation … account
for the vast majority of recent human adaptation. Surprisingly, our results also suggest that …

… Here, we used a DNA barcoding approach to generate the genotype-to-fitness map for
adaptation-driving mutations from a Saccharomyces cerevisiae population experimentally …

… that virus-interacting proteins undergo adaptation that is both … most adaptation in human
proteins is weakly beneficial, … The underlying processes driving weak and strong adaptation …

Proteins, due to the delicate balance of stabilizing and destabilizing interactions, are only …
Adaptation to extreme environments tends to shift the ‘mesophilic’ characteristics of proteins to …

… as a dominant driver of adaptation in … protein adaptation (p ≥ 0.17; S3 Fig). This indicates
that a high rate of citation for PPIPs is not statistically associated with their rate of adaptation. …

… 3ζ, which has been extensively characterized as a driver of pro-survival signaling. However,
… role of 14-3-3 proteins in supporting cellular adaptation to conditions in which mTOR activity …

… syringae can express three YopJ/YopP homologous proteins with various alleles that induce
host-adapted hypersensitive responses in different plants. Thus, whereas allelic variation of …