Survival kinases in ischemic preconditioning and postconditioning

DJ Hausenloy, DM Yellon - Cardiovascular research, 2006 - academic.oup.com
protein kinases play in mediating the cardioprotective effects of ischemic preconditioning
and postconditioning are reviewed in this article, and include protein kinases C, G, and A, …

Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C

H Tong, W Chen, C Steenbergen, E Murphy - Circulation research, 2000 - Am Heart Assoc
… 3-kinase (PI3-kinase) has a role in the signaling pathway in ischemic preconditioning (PC)
and whether it is proximal or distal to protein kinase C (PKC). Before 20 minutes of global …

Protein kinase A as another mediator of ischemic preconditioning independent of protein kinase C

S Sanada, H Asanuma, O Tsukamoto, T Minamino… - Circulation, 2004 - Am Heart Assoc
… (cAMP) in the myocardium during ischemic preconditioning (IP) limits infarct size independent
of protein kinase C (PKC). Accumulation of cAMP activates protein kinase A (PKA), which …

Role of protein kinase C as a cellular mediator of ischemic preconditioning: a critical review

BZ Simkhovich, K Przyklenk… - Cardiovascular research, 1998 - academic.oup.com
Protein kinase C (PKC) has been proposed as a primary cellular mediator of ischemic
preconditioning… the ‘PKC hypothesis’ of preconditioning, discuss the important technical limitations …

Protein kinase C. Its role in ischemic preconditioning in the rat.

ME Speechly-Dick, MM Mocanu, DM Yellon - Circulation research, 1994 - Am Heart Assoc
… investigated whether protein kinase C (PKC) plays a role inischemic preconditioning in the
… of PKC, were used to determine whether preconditioning could be blocked or triggered, re…

Signaling pathways in ischemic preconditioning

JM Downey, AM Davis, MV Cohen - Heart failure reviews, 2007 - Springer
… It was found that protection afforded by all of the trigger substances could be blocked by
protein kinase C (PKC) inhibitors [5–8] and PKC is thought to be this common target. Ligands to …

Protein kinases and kinase-modulated effectors in the late phase of ischemic preconditioning

CP Baines, JM Pass, P Ping - Basic research in cardiology, 2001 - Springer
… subcellular redistribution of total protein kinase C activity. Circ Res 81: 404–414 … protein
kinase C-dependent activation of Src and Lck tyrosine kinases during ischemic preconditioning

SAPKs regulation of ischemic preconditioning

M Sato, GA Cordis, N Maulik… - American Journal of …, 2000 - journals.physiology.org
kinases including protein kinase C and several mitogen-activated protein (MAP) kinases (3,26)…
ATP-dependent potassium channels play a crucial role in ischemic preconditioning (9). …

Role of protein kinase C in ischemic preconditioning: player or spectator?

G Brooks, DJ Hearse - Circulation research, 1996 - Am Heart Assoc
… , the fact that ischemic preconditioning failed to activate PKD … the duration of preconditioning
ischemia required to achieve … protein) and that it is this that leads to preconditioning. …

Ischemic preconditioning: from basic mechanisms to clinical applications

A Nakano, MV Cohen, JM Downey - Pharmacology & Therapeutics, 2000 - Elsevier
kinase cascade that is activated during the prolonged ischemia in the preconditioned heart.
Recent studies imply that p38 mitogen-activated protein kinase carries the signal from PKC …