… In conclusion, the first systems level analysis of proteome alterations during the course of
epileptogenesis identified several modules of highly connected proteins in the HC and PHC. …

… To identify sequential alterations of the genome, transcriptome, and proteome during
colorectal cancer progression, we have analyzed tissue samples from 36 patients, including the …

… proteomic approach. In addition to differential expression analysis to identify brain proteins
with significantly altered … -based systems-level analysis of our entire proteomic data set and …

… proteomic analysis of SH-SY5Y cells treated with MPP + (Alberio et al., 2014). Through this
analysis… to MPP + , the specific mitochondrial proteome alterations induced and how this toxic …

… of proteomes, are required for a more comprehensive understanding. The proteome is
extremely multifaceted owing to splicing and protein modifications, and this is further amplified by …

… all modifications present in the sample above a certain level, in our case substoichiometric
modifications … Unexpected and novel modifications can easily be revealed by ModifiComb ( …

… This technology gap has prompted the assumption that changing transcripts mediate
proportional protein alterations; however, most recent proteomic studies report poor correlation. For …

… at the heart of systems approaches to disease. Disease-perturbed networks initiate altered
responses that bring about pathologic phenotypes, such as the invasiveness of cancer cells. …

… modifications, all of which cannot be assayed by tracking mRNAs alone. Methods to study
proteomes … Proteomics has undergone a revolution, and novel technologies for the systematic …

… The simultaneous analysis of several proteome alterations by the meta-analysis allowed
authors to describe how the mitochondrial toxin MPP + alters the mitochondrial proteome, …