Genetic architectures of psychiatric disorders: the emerging picture and its implications

PF Sullivan, MJ Daly, M O'donovan - Nature Reviews Genetics, 2012 - nature.com
genetics of many of these conditions. In this Review, we discuss the genetics of nine cardinal
psychiatric disorders (namely, Alzheimer's disease, attention-deficit hyperactivity disorder, …

Large-scale genomics unveils the genetic architecture of psychiatric disorders

J Gratten, NR Wray, MC Keller, PM Visscher - Nature neuroscience, 2014 - nature.com
… the genetic architecture dramatically. In Box 2, we summarize the current state of knowledge
of genetics in psychiatric disorders. … disorders and we can be confident that many additional …

[PDF][PDF] Defining the genetic, genomic, cellular, and diagnostic architectures of psychiatric disorders

PF Sullivan, DH Geschwind - Cell, 2019 - cell.com
Genetic Architecture We review here what we have learned about the genetic architectures
of the 10 psychiatric disorders in Table 1. Because some of the basic techniques may be …

[HTML][HTML] Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders, and known risk factors

N Mullins, JE Kang, AI Campos, JRI Coleman… - … psychiatry, 2022 - Elsevier
… on psychiatric disorders using … genetic effects on SA mediated by psychiatric disorders. We
investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and …

The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges

OB Smeland, O Frei, CC Fan, A Shadrin… - Psychiatric …, 2019 - journals.lww.com
… We review how these tools have informed the current knowledge on the genetic architecture
of psychiatric disorders, focusing on schizophrenia, bipolar disorder and major depression, …

Genetic architecture of ADHD and overlap with other psychiatric disorders and cognition-related phenotypes

M Ribasés, M Mitjans, CA Hartman, MS Artigas… - Neuroscience & …, 2023 - Elsevier
disorders and traits. In this review, we summarize and interpret the existing literature on the
genetic architecture of these … Quantitative genetic studies indicate that genetic factors play a …

The molecular genetic architecture of attention deficit hyperactivity disorder

Z Hawi, TDR Cummins, J Tong, B Johnson, R Lau… - … psychiatry, 2015 - nature.com
… However, we argue that the current paradigm of analyzing psychiatric disorders such as
ADHD as a unitary construct works against the gains in power that substantial increases in …

Comparison of the Multivariate Genetic Architecture of Eight Major Psychiatric Disorders Across Sex

T Schwaba, TT Mallard, AX Maihofer, M Rhemtulla… - medRxiv, 2023 - medrxiv.org
… found that genetic architecture of individual psychiatric disorders is … genetic effects among
individual disorders have been difficult to interpret or relate to established multivariate genetic

Genetic architecture of schizophrenia: a review of major advancements

SE Legge, ML Santoro, S Periyasamy… - Psychological …, 2021 - cambridge.org
… and often chronic psychiatric disorder causing substantial … understanding of the genetic
architecture of schizophrenia has … common genetic architecture among psychiatric disorders

[HTML][HTML] The overlapping genetic architecture of psychiatric disorders and cortical brain structure

Z Sha, V Warrier, RAI Bethlehem, LM Schultz… - bioRxiv, 2023 - ncbi.nlm.nih.gov
… , surface area, and seven psychiatric disorders in approximately 700,000 individuals of …
genetic loci shared between psychiatric disorders and surface area, as well as 26 genetic