Ten challenges for clinical translation in psychiatric genetics

EM Derks, JG Thorp, ZF Gerring - Nature genetics, 2022 - nature.com
… that must be addressed before genetic findings can be translated into the clinic. In this … the
field of psychiatric genetics, focused on the robust and generalizable detection of genetic risk …

Four actionable bottlenecks and potential solutions to translating psychiatric genetics research: An expert review

JL Bourdon, RA Davies, EC Long - Public health genomics, 2021 - karger.com
… While working from a precision medicine perspective, Hutchison [124] noted the flaws of
precision medicine (sample size, lack of clinical translation, lack of replication, and emphasis on …

Translating insights from neuropsychiatric genetics and genomics for precision psychiatry

E Rees, MJ Owen - Genome Medicine, 2020 - Springer
… We then discuss how the complex genetics of psychiatric disorders have … psychiatry.
Finally, we consider the research agenda for translating recent findings in psychiatric genetics

[HTML][HTML] Lost in translation: the value of psychiatric clinical trials

JC Markowitz, BL Milrod - The Journal of Clinical Psychiatry, 2022 - legacy.psychiatrist.com
Clinical trials long represented the height of psychiatric research, the defining tests of
which of our treatments worked for particular diagnoses, how well they worked, how tolerable …

Autism genetics: opportunities and challenges for clinical translation

JAS Vorstman, JR Parr, D Moreno-De-Luca… - … Reviews Genetics, 2017 - nature.com
… insight should improve clinical care, … clinical application. In this Review, we discuss the
current challenges and opportunities for the translation of autism genetics knowledge into clinical

Translational Psychiatry: Bringing Pharmacogenomic Testing into Clinical Practice.

DK Hall-Flavin, TD Schneekloth… - … Psychiatry, 2010 - search.ebscohost.com
… The use of genetic testing to improve the efficacy of psychotropics is a clear example of
translational psychiatry. Given the promise of pharmacogenomic testing, it is prudent to analyze …

Translating genome-wide association findings into new therapeutics for psychiatry

G Breen, Q Li, BL Roth, P O'donnell, M Didriksen… - Nature …, 2016 - nature.com
… There are a number of initiatives in large, deeply phenotyped longitudinal samples aimed
at mapping psychiatric genetic discoveries onto imaging, neurophysiological, and behavioral …

[HTML][HTML] The translation of psychiatric genetic findings to the clinic

KM Kendall, D Duffin, J Doherty, R Irving… - Schizophrenia …, 2023 - Elsevier
… to access genetic counselling and testing. Here, we describe the development of the All …
Psychiatric Genomics Service, a collaborative effort between psychiatric and clinical genetics

Psychiatric genetics and the structure of psychopathology

JW Smoller, OA Andreassen, HJ Edenberg… - … psychiatry, 2019 - nature.com
… do genetic findings support or challenge our clinical nosology? Are there genetic boundaries
between psychiatric and … of psychopathology and the challenges for clinical translation. …

Translational epidemiology in psychiatry: linking population to clinical and basic sciences

MM Weissman, AS Brown, A Talati - … of general psychiatry, 2011 - jamanetwork.com
translational research. This article introduces the term translational epidemiology for psychiatry
… bedside or the population can also be translated to the benches of laboratory science. …