Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses

PM Visscher, ME Goddard, EM Derks, NR Wray - Molecular psychiatry, 2012 - nature.com
… perceived dichotomy between ‘common’ and ‘rare’ variants is not only false, but unhelpful
in making progress towards increasing our understanding of the genetic basis of psychiatric

Arguments for the sake of endophenotypes: examining common misconceptions about the use of endophenotypes in psychiatric genetics

DC Glahn, EEM Knowles, DR McKay… - … of Medical Genetics …, 2014 - Wiley Online Library
… At heart, arguments comparing the heritability of endophenotype and illness introduce a
false dichotomy in which studies of illness and endophenotype are assumed to be mutually …

Reflections on the relationship between psychiatric genetics and psychiatric nosology

KS Kendler - American Journal of Psychiatry, 2006 - Am Psychiatric Assoc
… for psychiatric disorders. In so doing, we examine how findings in psychiatric genetics
can impact on our understanding of the basic nature of psychiatric disorders. Especially, can …

What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn

KS Kendler - Molecular psychiatry, 2013 - nature.com
… This essay reviews what psychiatric genetics has taught us about the nature of psychiatric
illness and what we may yet learn from the new emerging findings. I organize this essay …

[HTML][HTML] Transcending false dichotomies and diagnostic silos to reduce disease burden in mental disorders

PD McGorry, B Nelson, SJ Wood, JL Shah… - … and psychiatric …, 2020 - Springer
… However, psychiatry constantly falls into the trap of setting up false dichotomies and is …
We argue that false dichotomies and binary thinking of this type might attract attention and …

Genetics in psychiatry: are the promises met?

B Bondy - The World Journal of Biological Psychiatry, 2011 - Taylor & Francis
… Thus, researchers were early confronted with many problems of psychiatric genetic studies,
such as the samples used for investigation in order to gain sufficient statistical power, the …

The “missing heritability” of psychiatric disorders: elusive genes or non-existent genes?

J Joseph - Applied Developmental Science, 2012 - Taylor & Francis
… If we view psychiatric genetics as a potential … psychiatric genetic researchers urged
potential funding sources not to “give up” on genome-wide association (GWA) studies of “psychiatric

Familial versus sporadic amyotrophic lateral sclerosis—a false dichotomy?

K Talbot - Brain, 2011 - academic.oup.com
… levels of understanding, most are aware that genetics plays a role in ALS at some level. The
standard response to questions about genetic risk is to make a concrete distinction between …

Distinguishing between the validity and utility of psychiatric diagnoses

R Kendell, A Jablensky - American journal of psychiatry, 2003 - Am Psychiatric Assoc
… At present, psychiatry is in a state of flux, and advances in neuroscience and genetics are
soon likely to challenge many of its current theoretical underpinnings, particularly those related …

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications

OA Andreassen, GFL Hindley, O Frei… - … Psychiatry, 2023 - Wiley Online Library
… nurture debate on the causes of mental illness is now understood to be a false dichotomy
38, 39 . Variation in risk of mental illness is neither solely due to variation in DNA or …