The pathogenesis of pulmonary fibrosis: a moving target

WA Wuyts, C Agostini, KM Antoniou… - European …, 2013 - Eur Respiratory Soc
Pulmonary fibrosis is the end stage of several diffuse parenchymal lung diseases (DPLDs), …
The most common form of pulmonary fibrosis, idiopathic pulmonary fibrosis (IPF), is a …

[HTML][HTML] Therapeutic targets in idiopathic pulmonary fibrosis

M Kolb, F Bonella, L Wollin - Respiratory medicine, 2017 - Elsevier
… In animal models of pulmonary fibrosis, nintedanib has demonstrated anti-fibrotic effects
including reductions in lung collagen content and morphometric fibrosis scores and reduced …

Moving target: shifting the focus to pulmonary sarcoidosis as an autoimmune spectrum disorder

Y Kaiser, A Eklund, J Grunewald - European Respiratory …, 2019 - Eur Respiratory Soc
… comprises a much more diverse group, commonly distinguished from LS by insidious onset,
slow progression and a higher risk of developing chronic disease and pulmonary fibrosis. …

MicroRNAs as potential targets for progressive pulmonary fibrosis

S Rajasekaran, P Rajaguru… - Frontiers in …, 2015 - frontiersin.org
… remodeling in pulmonary fibrosis is also crucial for uncovering novel therapeutic targets and
… In spite of some progress made to understand the development of severe pulmonary fibrosis

Therapeutic targets and early stage clinical trials for pulmonary fibrosis

S Sato, T Yanagihara, MRJ Kolb - Expert Opinion on Investigational …, 2019 - Taylor & Francis
pulmonary fibrosis via activation of growth factors, such as TGF-β1 [Citation16]. … target many
of the mediators and signaling pathways involved in the pathogenesis of pulmonary fibrosis. …

Evolving genomic approaches to idiopathic pulmonary fibrosis: moving beyond genes

DJ Kass, N Kaminski - Clinical and translational science, 2011 - Wiley Online Library
… In this review, we describe how genomic technologies have shaped our study of idiopathic
pulmonary fibrosis (IPF), a devastating, progressive scarring of the lung parenchyma, a …

Exploitation of novel molecular targets to treat idiopathic pulmonary fibrosis: a drug discovery perspective

B Vaidya, R Patel, A Muth… - Current Medicinal …, 2017 - ingentaconnect.com
pulmonary fibrosis (IPF) is a subset of pulmonary fibrosis in which the underlying factors
causing lung tissue fibrosis … Results of the study suggested miR-26a as a novel target for IPF pre…

Back to the future: historical perspective on the pathogenesis of idiopathic pulmonary fibrosis

PW Noble, RJ Homer - American journal of respiratory cell and …, 2005 - atsjournals.org
pulmonary medicine remains elucidating the pathogenesis of idiopathic pulmonary fibrosis
(… The diagnosis of IPF has been a moving target, and we are still without a gold standard. The …

Disease stratification in idiopathic pulmonary fibrosis: the dawn of a new era?

TM Maher - European Respiratory Journal, 2014 - Eur Respiratory Soc
… Research into idiopathic pulmonary fibrosis (IPF) has been rapidly gathering pace over
the past few years. This has been driven by a number of important factors, including the …

Drug discovery and development in idiopathic pulmonary fibrosis: challenges and opportunities

S Cruwys, P Hein, B Humphries, D Black - Drug Discovery Today, 2020 - Elsevier
… studies for the treatment of idiopathic pulmonary fibrosis (IPF). The most likely scenarios
are: ‘low proximity to SoC’: (1) Different target mechanisms might provide a greater window to …