Designing anticancer copper (II) complexes by optimizing 2-pyridine-thiosemicarbazone ligands

J Deng, P Yu, Z Zhang, J Wang, J Cai, N Wu… - European Journal of …, 2018 - Elsevier
… that the Cu N-4 modified 2-pyridine-thiosemicarbazone complexes could … Cu(II) tridentate
2-pyridine-thiosemicarbazone complexes have potential as promising multi-target anticancer

Anticancer potency of copper (II) complexes of thiosemicarbazones

NK Singh, AA Kumbhar, YR Pokharel… - Journal of Inorganic …, 2020 - Elsevier
… The attachment of a morpholine moiety to 2-formyl pyridine (iso) TSC in position 5 of 2-formyl
pyridine moiety yielded new water soluble TSC-morpholine hybrids and their …

Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics

KC Park, L Fouani, PJ Jansson, D Wooi, S Sahni… - Metallomics, 2016 - academic.oup.com
… This hypothesis was further supported by studies, in which tumour cells incubated with
pyridine carboxyaldehyde thiosemicarbazones (PCTs) were unable to convert ribonucleotides to …

Coordination to copper (II) strongly enhances the in vitro antimicrobial activity of pyridine-derived N (4)-tolyl thiosemicarbazones

IC Mendes, JP Moreira, AS Mangrich, SP Balena… - Polyhedron, 2007 - Elsevier
… , as well as that of its copper(II) complex [Cu(2Ac4mT)Cl], … activities of all thiosemicarbazones
and their copper(II) complexes … of pharmacological applications as anticancer, antiviral and …

Pyridine-based NNS tridentate chitosan thiosemicarbazones and their copper (II) complexes: synthesis, characterization, and anticancer activity

HS Adhikari, A Garai, KD Manandhar, PN Yadav - ACS omega, 2022 - ACS Publications
… Chitosan-functionalized pyridine-based thiosemicarbazones and their copper(II) …
pyridine-2-thiosemicarbazones and chitosan 2-acetyl pyridine-2-thiosemicarbazones, and their …

Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety

A Mrozek-Wilczkiewicz, K Malarz, M Rejmund… - European Journal of …, 2019 - Elsevier
Thiosemicarbazones (TSC) are a subclass of iron-chelating agents that are believed to have
an anticancer activity. The high potential for the application of this compound class can be …

A thiosemicarbazone copper (II) complex as a potential anticancer agent

ZY Ma, J Shao, WG Bao, ZY Qiang… - Journal of Coordination …, 2015 - Taylor & Francis
The preparation and the structure of a copper(II) complex, [Cu(4ML)Cl] (1) (H4ML = 2-acetylpyridine-4-methylthiosemicarbazone),
are described. Complex 1 crystallizes in a monoclinic …

Synthesis, crystal structure and bio-macromolecular interaction studies of pyridine-based thiosemicarbazone and its Ni (II) and Cu (II) complexes

A Basu, D Thiyagarajan, C Kar, A Ramesh, G Das - RSC advances, 2013 - pubs.rsc.org
thiosemicarbazones with a 2-oxoquinoline heterocycle unit exhibit outstanding DNA/protein
binding and antitumor … the presence of the heterocycles present in the thiosemicarbazones. …

Antifungal and antitumor activity of heterocyclic thiosemicarbazones and their metal complexes: current status

AE Liberta, DX West - Biometals, 1992 - Springer
… 1990 Chitin biosynthesis inhibition and fungicidal effect of thiosemicarbazones of 2-formyl-
and 2-acetylpyridine, their hydrogenated derivatives and copper complexes thereof. …

Copper (II) complexes of N (4)-substituted thiosemicarbazones derived from pyridine-2-carbaldehyde: Crystal structure of a binuclear complex

PF Rapheal, E Manoj, MRP Kurup - Polyhedron, 2007 - Elsevier
… and antitumor activities [1]. Complexation of such … copper(II) complexes with three ligands,
viz., pyridine-2-carbaldehyde N(4)-paramethoxyphenyl thiosemicarbazone (HL 1 ), pyridine-2-…