Reactivation of VX-inhibited human acetylcholinesterase by deprotonated pralidoxime. A complementary quantum mechanical study

JAV da Silva, AF Pereira, SR LaPlante, K Kuca… - Biomolecules, 2020 - mdpi.com
… This corroborates our hypothesis that the reactivation mechanism might be triggered by
the … to a better understanding of the mechanism of reactivation of HssAChE by pyridinium-…

Reactivation of phosphorylated acetylcholinesterase

F Hobbiger - Cholinesterases and anticholinesterase agents, 1963 - Springer
Reactivation by choline involves a combined acid-base attack by the two atoms of the …
During the past few years the antidotal action of hydroxamic acids and oximes which reactivate

Neural mechanisms of reactivation-induced updating that enhance and distort memory

PL St. Jacques, C Olm… - Proceedings of the …, 2013 - National Acad Sciences
… of memory reactivation on the neural mechanisms mediating … reactivation, as indexed
by an individual’s subjective sense of recollection, modulates the extent to which reactivation

A systematic analysis of signaling reactivation and drug resistance

BN Kholodenko, N Rauch, W Kolch, OS Rukhlenko - Cell reports, 2021 - cell.com
mechanisms that lead to complete pathway reactivation or overshoot, we identify network
topologies that can mediate full pathway reactivation … required for full reactivation or increase of …

Mechanisms mediating androgen receptor reactivation after castration

X Yuan, SP Balk - Urologic Oncology: Seminars and Original …, 2009 - Elsevier
reactivated at this stage of the disease. The molecular basis for this AR reactivation remains
unclear, but possible mechanismsmechanisms that appear to contribute to AR reactivation

Mechanisms of action of mixed solid− liquid antifoams: 3. Exhaustion and reactivation

ND Denkov, KG Marinova, C Christova, A Hadjiiski… - Langmuir, 2000 - ACS Publications
… In the present study, we continue the examination of the mechanisms of antifoam action
in the experimental system explored in ref 12: silica−silicone oil antifoams in solutions of the …

SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides

L Gorecki, J Korabecny, K Musilek, D Malinak… - Archives of …, 2016 - Springer
… The mechanism of reactivation is believed to include nucleophilic attack of phosphorus
atom of inhibited AChE, resulting in removal of OP bond and recovery of enzyme’s catalytic …

Heterogeneous HIV-1 reactivation patterns of disulfiram and combined disulfiram+ romidepsin treatments

A Kula, N Delacourt, S Bouchat, G Darcis… - JAIDS Journal of …, 2019 - journals.lww.com
… In this report, we evaluated reactivation potential of DSF alone or combined with romidepsin
in vitro in various latency cell lines of myeloid and T-lymphocytic origins and ex vivo in CD8 …

PRIMA-1 and PRIMA-1Met (APR-246): From Mutant/Wild Type p53 Reactivation to Unexpected Mechanisms Underlying Their Potent Anti-Tumor Effect in …

A Perdrix, A Najem, S Saussez, A Awada, F Journe… - Cancers, 2017 - mdpi.com
… Accordingly, reactivation of p53 appears as a quite … are PRIMA-1 (p53 reactivation and
induction of massive apoptosis … focus on their ability of p53 reactivation, an overview of their …

Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection

S Reuse, M Calao, K Kabeya, A Guiguen, JS Gatot… - PloS one, 2009 - journals.plos.org
… Here, we investigated the HIV-1 reactivating potential of a treatment combining HDACIs
used in human clinical trials or therapies (such as VPA and suberoylanilide hydroxamic acid […