Theoretical study on the aging and reactivation mechanism of tabun-inhibited acetylcholinesterase by using the quantum mechanical/molecular mechanical method

Y Li, L Du, Y Hu, X Sun, J Hu - Canadian Journal of Chemistry, 2012 - cdnsciencepub.com
… The aging mechanism and the reactivate mechanism were studied and elucidated in this
work. HLÖ-7 was proved to be able to reactivate tabun-inhibited AChE by a QM/MM study. We …

Reactivation of the coagulation system: rationale for long-term antithrombotic treatment

F Kontny - The American journal of cardiology, 1997 - Elsevier
Coronary artery thrombosis superimposed on a disrupted atherosclerotic plaque has emerged
as the pivotal pathophysiologic event in acute coronary syndromes (ie, unstable angina, …

[HTML][HTML] Risk of hepatitis B reactivation in patients treated with direct-acting antivirals for hepatitis C

I Aggeletopoulou, C Konstantakis… - World Journal of …, 2017 - ncbi.nlm.nih.gov
mechanisms of HBV reactivation in this setting. … mechanisms of HBV reactivation during
DAA therapy that is deemed necessary. Until then, careful monitoring for HBV reactivation should …

Elimination of cancer stem cells and reactivation of latent HIV-1 via AMPK activation: common mechanism of action linking inhibition of tumorigenesis and the potential …

J Finley - Medical Hypotheses, 2017 - Elsevier
… HIV-1 reactivation, facilitating virus … reactivation and promote CSC differentiation/apoptosis
(eg bryostatin-1, JQ1, metformin, butyrate, etc.) likely do so through a common mechanism

Reaction pathway for reactivation and aging of paraoxon-inhibited-acetylcholinesterase: A QM/MM study

X Tang, L Zhu, J Chen, J Hu, Q Zhang… - … and Theoretical Chemistry, 2014 - Elsevier
… In this work, the reactivation and aging mechanism of … Studies show that the reactivation
process of paraoxon–AChE … feasible to participate in the reactivation process than aging process…

Therapeutic potential of p53 reactivation in prostate cancer: Strategies and opportunities

S Kumari, V Sharma, R Tiwari, JP Maurya… - European Journal of …, 2022 - Elsevier
… Despite significant progress in the development of p53-reactivating compounds, there
remains so much to learn about the mechanism of action of these compounds. It would be …

Caspase activation, inhibition, and reactivation: a mechanistic view

Y Shi - Protein science, 2004 - Wiley Online Library
… 1), it was fully anticipated that the underlying mechanisms of caspase inhibition and
reactivation should be conserved as well. Supporting this prediction, the N-terminal IAP-binding …

Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors

M Merchant, J Moffat, G Schaefer, J Chan, X Wang… - PloS one, 2017 - journals.plos.org
reactivation, we next examined effects of combining MEK and ERK inhibition. The precise
definition of synergy with respect to combined actions … with independent mechanisms of action. …

Hepatitis B reactivation associated with immune suppressive and biological modifier therapies: current concepts, management strategies, and future directions

R Loomba, TJ Liang - Gastroenterology, 2017 - Elsevier
… Understanding the risk factors and mechanisms that cause HBV reactivation can help
understand and quantify the magnitude of the risk of HBV reactivation and its consequences. …

Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds

M Jokanovic, M Prostran - Current Medicinal Chemistry, 2009 - ingentaconnect.com
… Their mechanism of action is reactivation of acetylcholinesterase (AChE) inhibited by
organophosphorus agents. Organophosphorus compounds (OPC) are used as pesticides and …