Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement

M McCallum, N Czudnochowski, LE Rosen, SK Zepeda… - Science, 2022 - science.org
… to the human ACE2 entry receptor with high affinity and can … receptor recognition, we
determined cryo–electron microscopy (cryo-EM) structures of the prefusion-stabilized SARS-CoV-2 …

Cell entry by SARS-CoV-2

R Peng, LA Wu, Q Wang, J Qi, GF Gao - Trends in biochemical sciences, 2021 - cell.com
… In addition, some auxiliary receptors and cofactors are also involved that expand the host/tissue
tropism of SARS-CoV-2. After receptor engagement, specific proteases are required that …

Attachment factor and receptor engagement of SARS coronavirus and human coronavirus NL63

H Hofmann, A Marzi, T Gramberg, M Geier… - … : toward control of SARS …, 2006 - Springer
SARS patients recognize the SARSCoV-S protein and neutralize infection. Transient expression
of SARS-CoV-S … from healthy patients or SARS patients revealed that SARS patient sera …

[HTML][HTML] Mechanisms of SARS-CoV-2 entry into cells

CB Jackson, M Farzan, B Chen, H Choe - Nature reviews Molecular …, 2022 - nature.com
… cellular foundations for understanding the multistep SARS-CoV-2 entry process, including S
… of the S protein with ACE2, engagement of the receptor-binding domain of the S protein with …

Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking

L Liu, RG Casner, Y Guo, Q Wang, S Iketani, JFW Chan… - Immunity, 2023 - cell.com
SARS-CoV-2 spike. These antibodies prevented viral receptor engagement by locking the
receptor-… Deep mutational scanning showed that SARS-CoV-2 could mutate to escape 12-19, …

SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2

Q Lu, J Liu, S Zhao, MFG Castro, M Laurent-Rolle… - Immunity, 2021 - cell.com
coronavirus 2 (SARS-CoV-2) engagement with immune cells, most express little, if any, of
the canonical receptor of SARS-CoV-2, … Here, using a myeloid cell receptor-focused ectopic …

Can SARS-CoV-2 virus use multiple receptors to enter host cells?

LK Gadanec, KR McSweeney, T Qaradakhi… - International journal of …, 2021 - mdpi.com
… , could enhance docking sites for SARS-CoV-2, leading to … that SARS-CoV-2 may employ
additional receptors to gain … engagement between TLR3 and the S protein of SARS-CoV-…

SARSCoV‐2, early entry events

JP Chambers, J Yu, JJ Valdes… - Journal of …, 2020 - Wiley Online Library
… In typical cell culture systems, SARS-CoV gains entry via clathrin and nonclathrin pathways
following receptor engagement [84, 85], but treatment of cells with trypsin and/or trypsin-like …

Receptor-binding domain of SARS-CoV-2 is a functional αv-integrin agonist

EG Norris, XS Pan, DC Hocking - Journal of Biological Chemistry, 2023 - ASBMB
… Among the novel mutations distinguishing SARS-CoV-2 from similar coronaviruses is a
K403R substitution in the receptor-binding domain (RBD) of the viral spike (S) protein within its …

Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy

R Yamin, AT Jones, HH Hoffmann, A Schäfer, KS Kao… - Nature, 2021 - nature.com
… that selective engagement of activating Fcγ receptors results in … SARS-CoV-2 challenge
and for treatment of pre-infected animals. Our results highlight the importance of Fcγ receptor