… derived GPR65 is associated with intestinal antimicrobial defense, … Towards this end, Gpr65
ΔIEC mice and Gpr65 fl/fl … In contrast to Gpr65 fl/fl counterparts, Gpr65 ΔIEC mice displayed …

… receptors acts synergistically with interferon-γ to promote the development of classically
activated macrophages, which contributes to host defense … important role of GPR65 in regulating …

… , bile acid receptors such as GPR131 (TGR5) and proton-sensing receptors such as GPR65
… These receptors represent one of the main mechanisms whereby the gut microbiome affects …

… GPR65. Protons in extracellular acidic conditions bind to GPR65 [139] and act as surrogate
receptors … immunity with antimicrobial activities and are pivotal for intestinal defense. AMPs …

… receptor 65 (GPR65) and its inflammatory disease-associated Ile231Leu-coding variant in
inflammation control. GPR65 … that GPR65 Ile231Leu mice displayed impaired antibacterial …

… loci in antibacterial autophagy and … defense in both screens, GPR65 (G protein coupled
receptor 65) was selected for follow-up analysis because the association of IBD to the GPR65 …

… as GPR65 expressed on the gut epithelium and immune cells. GPR65 is an anti-inflammatory
Gαs-coupled receptor, … Loss of GPR65 impairs antibacterial autophagy, TH17 and TH22 …

… that GPR65 (G protein-coupled receptor 65), a H + -sensing G protein-coupled receptor
encoded by … defense [Citation79]. Epithelial cells or lymphoblasts from IBD patients carrying the …

… GPR65, suggesting that antibacterial … GPR65, an H + -sensing G protein-coupled receptor,
in maintaining lysosomal pH and thus lysosomal function.Citation 5 Polymorphisms in GPR65 …

… of chemokine receptor 1, IL-7 receptor, IL-13 receptor, and IL-… -mediated immune responses,
and GPR65, which is involved … These defenses include antimicrobial peptides, inflammatory …