Role of toll‐like receptors in modulation of cytokine storm signaling in SARS‐CoV‐2‐induced COVID‐19

M Manik, RK Singh - Journal of medical virology, 2022 - Wiley Online Library
… )-2, IL-4, IL-6, IL-8, IL-1β, and so forth. Characterized as “cytokine storm” that may have
occurred due to an imbalanced immune system. The cytokine storm is also considered to be one …

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

F Coperchini, L Chiovato, L Croce, F Magri… - Cytokine & growth factor …, 2020 - Elsevier
… that the term cytokine storm was first employed in describing the events modulating the onset
of … Cytokine storms characterize a wide spectrum of infectious and non-infectious diseases, …

Targeting the “cytokine storm” for therapeutic benefit

RV D'Elia, K Harrison, PC Oyston… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
… It produces the same inflammatory modulation as nicotine but is nontoxic, does not result in
an … GTS-21 inhibits pro-inflammatory cytokine release independent of the Toll-like receptor

[HTML][HTML] The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
… A cytokine storm (CS) is a clinically relevant condition that has been associated with several
… (DAMPs) with pattern recognition receptors evoke similar cytokine profiles in mammals. …

Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets

V Kumar - International immunopharmacology, 2020 - Elsevier
… Toll-like receptors (TLRs) are one of the major pattern recognition receptors (PRRs) … ,
which play a crucial role in generating cytokine storm. They recognize microbial-associated …

The cytokine storm of COVID-19: a spotlight on prevention and protection

L Pearce, SM Davidson, DM Yellon - Expert Opinion on …, 2020 - Taylor & Francis
… RIC may modulate adenosine receptors and … The cytokine storm of COVID-19 is an
important instigator of severe disease and multi-organ injury. We describe the immune-modulating

Cytokine storm in COVID-19: Potential therapeutics for immunomodulation

MM Rana - Journal of Research in Clinical Medicine, 2020 - library.2pressrelease.co.in
… AngII acts both as a vasoconstrictor and proinflammatory cytokine via angiotensin receptor
… reducing the clinical symptoms via modulating inflammatory cytokines in the different organs …

[HTML][HTML] Immunopathogenesis and treatment of cytokine storm in COVID-19

JS Kim, JY Lee, JW Yang, KH Lee, M Effenberger… - Theranostics, 2021 - ncbi.nlm.nih.gov
storm that occurs after chimeric antigen receptor (CAR) T cell … of cytokine storm, but it is
not easy to discriminate cytokine … to modulate macrophage dysfunction in cytokine storm. …

The cytokine storm of severe influenza and development of immunomodulatory therapy

Q Liu, Y Zhou, Z Yang - Cellular & molecular immunology, 2016 - nature.com
… for the treatment of cytokine storms in severe influenza, … -activated receptor agonists,
sphingosine-1-phosphate receptor … by modulating the expression of pro-inflammatory cytokines in …

Targeting purinergic receptors to suppress the cytokine storm induced by SARS-CoV-2 infection in pulmonary tissue

JLB Simões, HF Basso, GC Kosvoski, J Gavioli… - International …, 2021 - Elsevier
… Purinergic modulation may act as a dampening of the cytokine storm in COVID-19. … P2X
receptors modulate key responses in immune and inflammatory cells, such as cytokine release …