… In this study, we report that the nucleocapsid protein (N) of SARS-CoV-2 is a potent IFN
antagonist. SARS-CoV-2 N expression resulted in the attenuation of IFNs and downstream ISG …

… However, we found that N protein could not inhibit IFN-β production induced by … -β induction
pathways, toll-like receptor 3 (TLR3)- and RIG-I-like receptors (RLR)-dependent pathways. …

… RNA viruses activates the RIG-I Like Receptor pathway and initiates the expression of IFN-β …
β pathway, 293 T cells were transfected with the plasmids expressing SARS-CoV-2 proteins …

… Infection by SARS-CoV-2 activates the RIG-I-like receptor pathway and starts the … , the N
protein has a capacity to inactivate the RIG-I-like receptor and act against the IFN-I pathways by …

… on the TNF-R1 receptor pathway, since we observed no interaction between Fas-R signaling
cascade and inhibition by HTNV N protein. The TNFR-1 pathway is capable of activating …

… We noted that N protein also suppressed IFN-β production, … -I) pathway, which is the crucial
pattern recognition receptor (PRR) … that N protein interacted with the RIG-I protein through the …

… It is generally thought that SARS-CoV-2 N protein might interfere with the production of
type I IFNs by inhibiting multiple signal analyses of RIG-I-like receptor pathways (Figure 5B). …

… It is well known that infection by various RNA viruses activates the RIG-I-like receptor
pathway and initiates the expression of IFN-β, which is one of the main mechanisms of the host …

… disturbing the function of key proteins in antiviral immune signaling pathways, such as TANK…
-like receptors).74 The binding of an RNA ligand to these pathogen recognition receptors …

… Lastly, complement activation and the activation of signaling pathways through Toll-like
receptor 2 might be involved in increasing levels of IL-6 in the lungs of mice inoculated nasally …