Preclinical discovery and development of the casirivimab+ imdevimab cocktail for the treatment of novel coronavirus infection: the rise and fall

M Tuccori, I Convertino, S Ferraro… - Expert Opinion on …, 2022 - Taylor & Francis
… safety of subcutaneous REGEN-COV in preventing SARS CoV-2 … Their combination can
inhibit the binding of the SARS-CoV-2 … of regen-covTM (casirivimab and imdevimab) antibody

[HTML][HTML] Vaccinated patients have reduced rates of hospitalization after receiving casirivimab and imdevimab for COVID-19

T Zitek, K Jodoin, T Kheradia, R Napolillo… - The American journal …, 2022 - ncbi.nlm.nih.gov
… name REGEN-COV), a neutralizing monoclonal antibody cocktail, … The CDC recommends
the use of monoclonal antibody … These were assessed by a combination of medical record …

Optimization of anti-SARS-CoV-2 neutralizing antibody therapies: roadmap to improve clinical effectiveness and implementation

K van der Straten, MJ van Gils, SW de Taeye… - Frontiers in Medical …, 2022 - frontiersin.org
… The neutralization potency of the monoclonal antibody combination therapy Ronapreve (REGN-COV)
and Evusheld (AZD7442) are not substantially influenced against any VOCs, …

[HTML][HTML] Doubtful clinical benefit of casirivimab-imdevimab treatment for disease severity outcome of high-risk patients with SARS-CoV-2 delta variant infection

N Shopen, M Dekel, M Mizrahi… - European Journal of …, 2022 - ncbi.nlm.nih.gov
REGEN-COV, a combination of 2 neutralizing monoclonal antibodies, Casirivimab and
Imdevimab … found monoclonal antibody treatment to be associated with reduced hospitalization in …

Examining protective effects of SARS-CoV-2 neutralizing antibodies after vaccination or monoclonal antibody administration

D Follmann, MP O'Brien, J Fintzi, MP Fay… - Nature …, 2023 - nature.com
… Our analyses are for a specific mAb combination and vaccine, similar analyses for other …
patents for the REGEN-COV antibody cocktail. AH owns stock in Regeneron and Pfizer. K.-…

Current vaccine strategies against SARS_CoV-2 only poorly protect kidney transplant recipients

D Ducloux, J Bamoulid, M Chabannes… - Journal of …, 2022 - journalofinfection.com
antibodies is the strategy of choice. The first available antibody combination was REGEN
CoV. … In our cohort, no COVID 19 infection was observed in patients treated with REGEN CoV, …

Monoclonal antibody therapies against SARS-CoV-2

D Focosi, S McConnell, A Casadevall… - The Lancet Infectious …, 2022 - thelancet.com
… Monoclonal antibodies (mAbs) targeting the spike protein of SARS-CoV-2 have been widely
used in … REGEN-COV antibody combination and outcomes in outpatients with COVID-19. …

Endogenous antibody responses in REGN-COV2-treated SARS-CoV-2-infected individuals

A Kurshan, LB Snell, L Prior, JCH Tam… - Oxford Open …, 2023 - academic.oup.com
… Whilst antibody … -CoV-2 generated in mAb-treated patients and therefore ongoing susceptibility
to future infections. Here we measure the endogenous antibody response in SARS-CoV-2…

[HTML][HTML] Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV-2 Delta variant (B. 1.617 …

L Tatham, A Kipar, J Sharp, E Kijak, J Herriott, M Neary… - BioRxiv, 2023 - ncbi.nlm.nih.gov
… The purpose of this study was to investigate the ability of monoclonal antibody combinations
to mitigate pulmonary and neurological manifestations of SARS-CoV-2 infection using …

Isolation of human monoclonal antibodies with neutralizing activity to a broad spectrum of SARS-CoV-2 viruses including the Omicron variants

M Ueno, N Iwata-Yoshikawa, A Matsunaga, T Okamura… - Antiviral research, 2022 - Elsevier
… could neutralize REGN-COV escape mutants, our findings suggest that the combination of
EV053273 and … The monoclonal antibody combination REGEN-COV protects against SARS-…