… In this work, we first show that in vitro escape variants are … We extend these findings by
showing that escape variants can … ), whereas the REGEN-COV combination fully protects against …

… of minor virus variants in SARS-COV-2 isolates found in COVID-… non-competing antibodies,
REGEN-COV, not only provides full … Furthermore, by comparing escape mutations identified …

… with an E406W mutation were able to escape from both REGEN-COV compounds 31 . This
… Strikingly, for REGEN-COV, viruses evolve pairs of mutations to escape both components of …

… escape maps showed that three of these mutations escaped REGN10933 and that one
escaped … , we have completely mapped mutations that escape three leading anti–SARS-CoV-2 …

… or with the potential for immune escape was eventually our main … measures with concern
for virus mutation in a patient with … mutations and predict the efficacy of the anti-spike REGEN-…

… There is also a need for therapeutic agents that remain effective against emerging SARS-CoV-2
variants of concern, which contain mutations that attenuate immunity resulting from …

… REGEN-COV treatment, we find multiple newly emerged mutations, including 4 spike mutations
… sufficient to escape effective neutralization by both the REGEN-COV monoclonal cocktail …

… evaluate whether subcutaneously administered REGEN-COV could be used … CoV-2. We
used a household-contact trial design to assess whether REGEN-COV could prevent SARS-CoV…

… These breakthrough COVID-19 infections due to the Omicron variant are consistent with
in vitro evidence of a complete escape of SARS-CoV-2 variant Omicron to casirivimab and …

… -CoV-2 receptor-binding domain (RBD) E406W mutation abrogates neutralization mediated
by the REGEN-COV … of the E406W-mediated escape from the REGEN-COV cocktail and the …