[HTML][HTML] The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies

R Copin, A Baum, E Wloga, KE Pascal, S Giordano… - Cell, 2021 - cell.com
… in SARS-COV-2 isolates … REGEN-COV, as well as in preclinical in vitro studies using single,
dual, or triple antibody combinations, and in hamster in vivo studies using REGEN-COV or …

REGEN-COV protects against viral escape in preclinical and human studies

R Copin, A Baum, E Wloga, KE Pascal, S Giordano… - bioRxiv, 2021 - biorxiv.org
… effects of antiviral antibody treatment on virus evolution in humans. As predicted by our in
vitro and in vivo preclinical studies, treatment with the REGEN-COV cocktail in the clinic did not …

Regen med therapeutic opportunities for fighting COVID-19

A Atala, A Henn, M Lundberg, T Ahsan… - Stem Cells …, 2021 - academic.oup.com
… This article addresses why SARS-CoV-2 is so different from … carry the human ACE2 gene for
research on SARS-CoV are … therapies and vaccines (clinical and preclinical), COVID-19 trial …

Subcutaneous REGEN-COV antibody combination to prevent Covid-19

MP O'Brien, E Forleo-Neto, BJ Musser… - … England Journal of …, 2021 - Mass Medical Soc
… RT-qPCR serologic testing at a central laboratory to be negative for SARS-CoV-2 at baseline;
… predicted neutralization target concentration (according to preclinical data) as early as the …

REGEN-COV antibody combination and outcomes in outpatients with Covid-19

DM Weinreich, S Sivapalasingam… - … England Journal of …, 2021 - Mass Medical Soc
… In vitro studies showed that this antibody cocktail, REGEN-COV, retains activity against
current … the predicted neutralization target concentration based on in vitro and preclinical data. …

REGEN-COV antibody cocktail clinical outcomes study in Covid-19 outpatients

DM Weinreich, S Sivapalasingam, T Norton, S Ali… - MedRxiv, 2021 - medrxiv.org
… In vitro studies demonstrated that REGEN-COV retains activity against current VOCs …
preclinical studies predict REGEN-COV protection against emergence of viral escape in humans

REGEN-COV® for Treatment of Hospitalized Patients with Covid-19

S Somersan-Karakaya, E Mylonakis, VP Menon… - medRxiv, 2021 - medrxiv.org
… by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is highly variable; while
… morbidity and mortality associated with SARS-CoV-2 infection in hospitalized patients. In a …

[HTML][HTML] Subcutaneous REGEN-COV antibody combination in early asymptomatic SARS-Cov-2 infection: a randomized clinical trial

MP O'Brien, E Forleo-Neto, N Sarkar, F Isa, P Hou… - MedRxiv, 2021 - ncbi.nlm.nih.gov
… shown consistently in REGEN-COV clinical studies, a larger … concentration, based on in vitro
and preclinical data, 19 – 21 on … evidence from phase 3 REGEN-COV clinical studies 24 , 28 …

REGEN-COV Antibody Combination in Outpatients With COVID-19–Phase 1/2 Results

T Norton, S Ali, S Sivapalasingam, H Gao, R Bhore… - medRxiv, 2021 - medrxiv.org
… The two human sequence antibodies, casirivimab and … SARS-CoV-2 serology testing
and central lab PCR testing were … concentration based on in vitro and preclinical data [10-12]. …

[HTML][HTML] Effectiveness of REGENCOV antibody cocktail against the B. 1.617. 2 (delta) variant of SARS‐CoV‐2: A cohort study

S Banu, M Sasikala, KVL Parsa… - Journal of internal …, 2022 - ncbi.nlm.nih.gov
… of REGENCOV on the delta variant of SARS‐CoV‐2 is … values in patients receiving
REGENCOV reveals enhanced viral … REGENCOV antibody cocktail‐treated high‐risk …