[HTML][HTML] Expanding role for the apelin/APJ system in physiopathology

C Carpéné, C Dray, C Attané, P Valet… - Journal of physiology …, 2007 - ncbi.nlm.nih.gov
Apelin is a bioactive peptide known as the ligand of the G protein-coupled receptor APJ.
Diverse active apelin peptides exist under the form of 13, 17 or 36 amino acids, originated …

Apelin, diabetes, and obesity

I Castan-Laurell, C Dray, C Attané, T Duparc, C Knauf… - Endocrine, 2011 - Springer
Apelin is a peptide known as the ligand of the G-protein-coupled receptor APJ. Several
active apelin forms exist such as apelin-36, apelin-17, apelin-13, and the pyroglutamated …

The therapeutic potentials of apelin in obesity-associated diseases

I Castan-Laurell, C Dray, P Valet - Molecular and Cellular Endocrinology, 2021 - Elsevier
Apelin, a peptide with several active isoforms ranging from 36 to 12 amino acids and its
receptor APJ, a G-protein-coupled receptor, are widely distributed. However, apelin has …

[PDF][PDF] The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

AM O'Carroll, SJ Lolait, LE Harris, GR Pope - J Endocrinol, 2013 - academia.edu
The apelin receptor (APJ; gene symbol APLNR) is a member of the G protein-coupled
receptor gene family. Neural gene expression patterns of APJ, and its cognate ligand apelin …

[HTML][HTML] The role of apelin in cardiovascular diseases, obesity and cancer

MB Wysocka, K Pietraszek-Gremplewicz… - Frontiers in …, 2018 - frontiersin.org
Apelin is an endogenous peptide identified as a ligand of the G protein-coupled receptor
APJ. Apelin belongs to the family of adipokines, which are bioactive mediators released by …

[HTML][HTML] Apelin and energy metabolism

C Bertrand, P Valet, I Castan-Laurell - Frontiers in physiology, 2015 - frontiersin.org
A wide range of adipokines identified over the past years has allowed considering the white
adipose tissue as a secretory organ closely integrated into overall physiological and …

Apelin and its receptor APJ in cardiovascular diseases

XH Yu, ZB Tang, LJ Liu, H Qian, SL Tang, DW Zhang… - Clinica Chimica …, 2014 - Elsevier
Apelin is an adipokine that has been identified as an endogenous ligand for the orphan
receptor APJ. Apelin and APJ are expressed in a diverse range of tissues with particular …

[PDF][PDF] Apelin stimulates glucose uptake but not lipolysis in human adipose tissue ex vivo

C Attané, D Daviaud, C Dray, R Dusaulcy… - Journal of molecular …, 2011 - Citeseer
Apelin is a peptide present in different cell types and secreted by adipocytes in humans and
rodents. Apelin exerts its effects through a G-protein-coupled receptor called APJ. During the …

Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans

C Dray, C Debard, J Jager, E Disse… - American journal …, 2010 - journals.physiology.org
Apelin, an adipocyte-secreted factor upregulated by insulin, is increased in adipose tissue
(AT) and plasma with obesity. Apelin was recently identified as a new player in the control of …

Hypothalamic actions of apelin on energy metabolism: new insight on glucose homeostasis and metabolic disorders

C Knauf, A Drougard, A Fournel… - Hormone and …, 2013 - thieme-connect.com
Hypothalamus is key area implicated in control of glucose homeostasis. This structure
integrates nervous and peripheral informations to adapt a response modifying peripheral …