Eukaryotic cells contain small, highly abundant, nuclear-localized non-coding RNAs
[snRNAs (small nuclear RNAs)] which play important roles in splicing of introns from primary …

Recent genetic and biochemical experiments have revealed an intimate and dynamic role
for small nuclear RNAs (snRNAs) in multiple steps of RNA-splicing reactions. Both snRNA …

Numerous non-coding RNAs are known to be involved in the regulation of gene expression.
In this work, we analyzed RNAs that co-immunoprecipitated with human RNA polymerase II …

The minor U12-dependent class of eukaryotic nuclear pre-mRNA introns is spliced by a
distinct spliceosomal mechanism that requires the function of U11, U12, U5, U4atac, and …

Genetic and biochemical studies have recently shown that the splice sites in nuclear pre-
mRNAs are aligned for the transesterification reactions through a collaboration between U5 …

All eukaryotic cells contain multiple small nuclear RNAs, designated U-sn At present ten U-
snRNAs have been identified; they account for about 1% total mammalian cellular RNA. Of …

The nucleus contains a large number of metabolically stable, 60-450-nt-long small nuclear
RNAs (snRNAs) that exist in the form of ribonucleoproteins (snRNPs)(Yu et al., 1999). Each …

This chapter deals with the posttranscriptional modifications of metabolically stable small
nuclear RNAs (snRNAs) and the possible link to the function of these molecules. A study of …

In the 20 years since the discovery that many eukaryotic genes are interrupted by non-
coding intervening sequences, or introns, biologists have learnt a tremendous amount about …

Removal of introns from precursor messenger RNA (pre-mRNA) and some noncoding
transcripts is an essential step in eukaryotic gene expression. In the nucleus, this process of …