Microglial activation and macrophage infiltration into the CNS are common features of CNS
autoimmune disease and of chronic neurodegenerative diseases. Because these cells …

Neuroinflammation is a common feature in neurodegenerative diseases and strategies to
modulate neuroinflammatory processes are increasingly considered as therapeutic options …

Immune responses in the CNS are common, despite its perception as a site of immune
privilege. These responses can be mediated by resident microglia and astrocytes, which are …

Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

INTRODUCTION Under homeostasis, the central nervous system (CNS) hosts microglia
(MG) and CNS-associated macrophages (CAMs). During experimental autoimmune …

Microglia, the resident immune cells of the central nervous system, are not a homogeneous
population; their morphology, molecular profile, and even their ultrastructure greatly vary …

Microglia form a unique population of brain-resident macrophages. Although microglia have
been involved in multiple disorders of the central nervous system (CNS), the issue of …

Microglia originate from erythromyeloid progenitors (EMPs) in the yolk sac and develop in
the forming CNS. Microglia are fundamental for the development and function of a healthy …

Microglia—from micro (small) and glia (glue)—are the resident immune cells of the brain
and constantly patrol the cerebral microenvironment to respond to pathogens and damage …

Microglia, the parenchymal brain macrophages of the central nervous system, have
emerged as critical players in brain development and homeostasis. The immune functions of …