Back to the future: spatiotemporal determinants of NK cell antitumor function

JH Li, TE O'Sullivan - Frontiers in Immunology, 2022 - frontiersin.org
NK cells play a crucial role in host protection during tumorigenesis. Throughout tumor
development, however, NK cells become progressively dysfunctional through a combination …

Rapid establishment of a tumor-retained state curtails the contribution of conventional NK cells to anti-tumor immunity in solid cancers

I Dean, CYC Lee, ZK Tuong, Z Li, CA Tibbitt, C Willis… - bioRxiv, 2023 - biorxiv.org
Immune cell dysfunction within the tumor microenvironment undermines the control of
cancer progression. NK cells play critical roles in limiting early tumor growth and metastatic …

Plasticity of NK cells in Cancer

D Corvino, A Kumar, T Bald - Frontiers in Immunology, 2022 - frontiersin.org
Natural killer (NK) cells are crucial to various facets of human immunity and function through
direct cytotoxicity or via orchestration of the broader immune response. NK cells exist across …

Mechanisms of NK cell dysfunction in the tumor microenvironment and current clinical approaches to harness NK cell potential for immunotherapy

R Devillier, AS Chrétien, T Pagliardini… - Journal of Leucocyte …, 2021 - academic.oup.com
NK cells are innate immune cells with inherent capabilities in both recognizing and killing
cancer cells. NK cell phenotypes and functional alterations are being described with …

The adverse impact of tumor microenvironment on NK-cell

Z Hu, X Xu, H Wei - Frontiers in Immunology, 2021 - frontiersin.org
NK cells are considered an important component of innate immunity, which is the first line of
defensing against tumors and viral infections in the absence of prior sensitization. NK cells …

New job for NK cells: architects of the tumor microenvironment

L Dyck, L Lynch - Immunity, 2018 - cell.com
NK cells control tumor growth directly through targeted cytotoxic granule release or cytokine
secretion and indirectly by orchestrating anti-tumor immune responses. In this issue of …

Shaping of NK cell responses by the tumor microenvironment

A Stojanovic, MP Correia, A Cerwenka - Cancer Microenvironment, 2013 - Springer
Natural killer (NK) cells belong to the innate immune system and are potent cytolytic and
cytokine-producing effector cells in response to tumor targets. NK cell based anti-tumor …

Tumor-primed NK cells: waiting for the green light

M Sabry, MW Lowdell - Frontiers in Immunology, 2013 - frontiersin.org
The functional impairment of natural killer (NK) cells has been frequently reported in cancer
studies. As one of the central components of host anti-tumor immunity, NK cells exert cellular …

Influence of the tumor microenvironment on NK cell function in solid tumors

O Melaiu, V Lucarini, L Cifaldi, D Fruci - Frontiers in immunology, 2020 - frontiersin.org
Natural killer (NK) cells are a population of innate lymphoid cells playing a pivotal role in
host immune responses against infection and tumor growth. These cells have a powerful …

Arrested development: suppression of NK cell function in the tumor microenvironment

L Riggan, S Shah, TE O'Sullivan - Clinical & Translational …, 2021 - Wiley Online Library
Natural killer (NK) cells are cytotoxic innate lymphocytes that protect against viral infection
and tumor metastasis. Despite their inherent ability to kill a broad range of virally infected …