ABSTRACT A fundamental aspect in the morphogenesis of a polarized epithelium is the
formation of structurally and functionally distinct apical and basal-lateral domains of the …

The development of cell polarity in Madin-Darby canine kidney (MDCK) cells has been
analyzed under conditions in which cells are induced to form multicellular epithelial cysts in …

The development of polarized epithelial cells from unpolarized precursor cells follows
induction of cell-cell contacts and requires resorting of proteins into different membrane …

Abstract Development and maintenance of cell-surface polarity in epithelial cells requires
specialized localization of proteins to functionally and structuraally distinct plasma …

Epithelia are tissues that form selective permeability barriers and regulate the exchange of
substances between the external milieu and the internal environment of an organism. In …

The recent discovery of widely distributed targeting determinants, which govern the
polarized cell-surface distribution of plasma membrane proteins in epithelial cells, has …

Polarized epithelial cells form barriers between biological compartments and modulate the
ionic environment of those compartments by vectorial transport of ions and solutes across …

We have been interested in determining how epithelial cells generate and maintain their
characteristically polarized distributions of membrane proteins. Our efforts to date strongly …

Polarized epithelial cells continuously sort transmembrane proteins to either apical or
basolateral plasma membrane domains. Research in recent years has made tremendous …

Epithelial cell polarity depends on the continuous sorting of plasma membrane proteins.
While various sorting signals and pathways have been identified, only recently has a protein …