Hydrogen sulfide-releasing anti-inflammatory drugs

JL Wallace - Trends in pharmacological sciences, 2007 - cell.com
Non-steroidal anti-inflammatory drugs are among the most commonly used drugs. Despite
efforts to produce non-steroidal anti-inflammatory drugs that do not cause gastrointestinal …

A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo

CW Huang, W Feng, MT Peh, K Peh, BW Dymock… - Pharmacological …, 2016 - Elsevier
Exogenous hydrogen sulfide (H 2 S) is known to exert anti-inflammatory effects both in
macrophages and in animal models. In this study, we first showed that NaHS caused a …

A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications

CR Powell, KM Dillon, JB Matson - Biochemical pharmacology, 2018 - Elsevier
Hydrogen sulfide (H 2 S) is a ubiquitous small gaseous signaling molecule, playing an
important role in many physiological processes and joining nitric oxide and carbon …

H2S and Inflammation: An Overview

M Bhatia - … , Biochemistry and Pharmacology of Hydrogen Sulfide, 2015 - Springer
Inflammation is a response to traumatic, infectious, post-ischemic, toxic, or autoimmune
injury. However, uncontrolled inflammation can lead to disease, and inflammation is now …

Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-κB pathway

L Zhi, AD Ang, H Zhang, PK Moore… - Journal of Leucocyte …, 2007 - academic.oup.com
Hydrogen sulfide (H2S) is now considered an endogenous, gaseous mediator, which has
been demonstrated to be involved in many inflammatory states. However, the mechanism of …

Hydrogen, a novel therapeutic molecule, regulates oxidative stress, inflammation, and apoptosis

Y Tian, Y Zhang, Y Wang, Y Chen, W Fan… - Frontiers in …, 2021 - frontiersin.org
Molecular hydrogen (H2) is a colorless and odorless gas. Studies have shown that H2
inhalation has the therapeutic effects in many animal studies and clinical trials, and its …

Could histamine H1 receptor antagonists be used for treating COVID-19?

C Qu, GM Fuhler, Y Pan - International Journal of Molecular Sciences, 2021 - mdpi.com
COVID-19 has rapidly become a pandemic worldwide, causing extensive and long-term
health issues. There is an urgent need to identify therapies that limit SARS-CoV-2 infection …

[HTML][HTML] H2S attenuates LPS-induced acute lung injury by reducing oxidative/nitrative stress and inflammation

HX Zhang, SJ Liu, XL Tang, GL Duan, X Ni… - Cellular Physiology and …, 2016 - karger.com
Background: Hydrogen sulfide (H 2 S), known as the third endogenous gaseous transmitter,
has received increasing attention because of its diverse effects, including angiogenesis …

Emerging pharmacological tools to control hydrogen sulfide signaling in critical illness

E Marutani, F Ichinose - Intensive care medicine experimental, 2020 - Springer
Hydrogen sulfide (H 2 S) has long been known as a toxic environmental hazard. Discovery
of physiological roles of H 2 S as a neurotransmitter by Kimura and colleagues triggered an …

[HTML][HTML] Decreased availability of nitric oxide and hydrogen sulfide is a hallmark of COVID-19

P Dominic, J Ahmad, R Bhandari, S Pardue… - Redox biology, 2021 - Elsevier
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is involved in
a global outbreak affecting millions of people who manifest a variety of symptoms …