In vivo confocal microscopy of the human cornea in the assessment of peripheral neuropathy and systemic diseases

EF Wang, SL Misra, DV Patel - BioMed research international, 2015 - Wiley Online Library
In vivo confocal microscopy (IVCM) of the living human cornea offers the ability to perform
repeated imaging without tissue damage. Studies using corneal IVCM have led to significant …

In vivo confocal microscopy of corneal nerves: analysis and clinical correlation

A Cruzat, D Pavan-Langston… - Seminars in …, 2010 - Taylor & Francis
Corneal confocal microscopy is a growing technique for the study of the cornea at the
cellular level, providing images comparable to ex vivo histochemical methods. In vivo …

In vivo confocal microscopy of human corneal nerves in health, in ocular and systemic disease, and following corneal surgery: a review

DV Patel, CNJ McGhee - British Journal of Ophthalmology, 2009 - bjo.bmj.com
The exponential evolution of in vivo confocal microscopy (IVCM) has led to a significant
enhancement in our knowledge of the living cornea in both its physiological and …

In vivo confocal microscopy of corneal nerves in health and disease

A Cruzat, Y Qazi, P Hamrah - The ocular surface, 2017 - Elsevier
In vivo confocal microscopy (IVCM) is becoming an indispensable tool for studying corneal
physiology and disease. Enabling the dissection of corneal architecture at a cellular level …

Corneal confocal microscopy: a new technique for early detection of diabetic neuropathy

N Papanas, D Ziegler - Current diabetes reports, 2013 - Springer
Corneal confocal microscopy (CCM) is a noninvasive method for the study of human cornea
in vivo. It has increasingly been used to assess the morphology of the sub-basal corneal …

Corneal confocal microscopy: a non-invasive surrogate of nerve fibre damage and repair in diabetic patients

RA Malik, P Kallinikos, CA Abbott, CHM van Schie… - Diabetologia, 2003 - Springer
Aims/hypothesis The accurate detection, characterization and quantification of human
diabetic neuropathy are important to define at risk patients, anticipate deterioration, and …

3D confocal laser-scanning microscopy for large-area imaging of the corneal subbasal nerve plexus

S Allgeier, A Bartschat, S Bohn, S Peschel… - Scientific reports, 2018 - nature.com
The capability of corneal confocal microscopy (CCM) to acquire high-resolution in vivo
images of the densely innervated human cornea has gained considerable interest in using …

Corneal confocal microscopy to image small nerve fiber degeneration: ophthalmology meets neurology

IN Petropoulos, G Bitirgen, M Ferdousi… - Frontiers in Pain …, 2021 - frontiersin.org
Neuropathic pain has multiple etiologies, but a major feature is small fiber dysfunction or
damage. Corneal confocal microscopy (CCM) is a rapid non-invasive ophthalmic imaging …

The inferior whorl for detecting diabetic peripheral neuropathy using corneal confocal microscopy

IN Petropoulos, M Ferdousi, A Marshall… - … & visual science, 2015 - iovs.arvojournals.org
Purpose.: In vivo corneal confocal microscopy (CCM) is increasingly used as a surrogate
endpoint in studies of diabetic polyneuropathy (DPN). However, it is not clear whether …

In vivo confocal microscopy of corneal small fiber damage in diabetes mellitus

EM Messmer, C Schmid-Tannwald, D Zapp… - Graefe's Archive for …, 2010 - Springer
Background Advanced diabetic keratopathy includes impaired corneal sensation, reduced
tear secretion, conjunctival squamous metaplasia, and goblet cell loss, as well as …