The pathophysiology of acute illness and injury recognizes three main effectors: infection,
trauma, and ischemia-reperfusion injury. Each of them can act by itself or in combination …

Massive bleeding is the most common cause of death on the battlefield. When not fatal,
massive blood loss results in critical ischemic injury to multiple organ systems and tissues …

Zusammenfassung Vom 29. Februar bis zum 04. März 2000 fand in München unter der
Leitung von Prof. Dr. E. Faist der 5th World Congress on Trauma, Shock, Inflammation and …

Research on the immune consequences of shock and trauma by multiple laboratories over
more than 20 years has resulted in the following paradigm, which is currently accepted by …

Organisms respond to injury by attempting to restore homeostasis, which involves a
coordination of the immune, inflammatory, cardiovascular, endocrine, and nervous systems …

Immediate and early trauma death rates are determined by “first hits” such as hypoxia,
hypotension and organ injury, while late mortality correlates closely with “second hits” such …

Multiple organ failure, multiple organ dysfunction syndrome, and the systemic inflammatory
response syndrome are problems of medical progress and intensive care units (ICUs) and …

Multiple organ dysfunction syndrome (MODS) is caused by an overwhelming, uncontrolled
systemic inflammatory response that is activated by a number of hostile stimuli including …

In 1872, Gross referred to shock as the" manifestation of the rude unhinging of the
machinery of life.,,[We now know that shock, at its most fundamental level, represents the …

The pathophysiology of sepsis can be regarded as a series of steps, beginning with the
invasion of normally sterile tissue by microbes and the elaboration of various pro …