Analysis of shared heritability in common disorders of the brain
Brainstorm Consortium, V Anttila, B Bulik-Sullivan… - Science, 2018 - science.org
INTRODUCTION Brain disorders may exhibit shared symptoms and substantial
epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed …
epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed …
Analysis of shared heritability in common disorders of the brain
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share
symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing …
symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing …
[HTML][HTML] Analysis of shared heritability in common disorders of the brain
Brainstorm Consortium - Science (New York, NY), 2018 - ncbi.nlm.nih.gov
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share
symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing …
symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing …
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
MJ Gandal, JR Haney, NN Parikshak, V Leppa… - Science, 2018 - science.org
The predisposition to neuropsychiatric disease involves a complex, polygenic, and
pleiotropic genetic architecture. However, little is known about how genetic variants impart …
pleiotropic genetic architecture. However, little is known about how genetic variants impart …
Cross-trait assortative mating is widespread and inflates genetic correlation estimates
The observation of genetic correlations between disparate human traits has been
interpreted as evidence of widespread pleiotropy. Here, we introduce cross-trait assortative …
interpreted as evidence of widespread pleiotropy. Here, we introduce cross-trait assortative …
Exploring the genetic overlap between twelve psychiatric disorders
The widespread comorbidity among psychiatric disorders demonstrated in epidemiological
studies,,,–is mirrored by non-zero, positive genetic correlations from large-scale genetic …
studies,,,–is mirrored by non-zero, positive genetic correlations from large-scale genetic …
Charting the landscape of genetic overlap between mental disorders and related traits beyond genetic correlation
Objective: Mental disorders are heritable and polygenic, and genome-wide genetic
correlations (rg) have indicated widespread shared genetic risk across multiple disorders …
correlations (rg) have indicated widespread shared genetic risk across multiple disorders …
Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis
We interrogate the joint genetic architecture of 11 major psychiatric disorders at
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …
One gene, many neuropsychiatric disorders: lessons from Mendelian diseases
Recent human genetic studies have consistently shown that mutations in the same gene or
same genomic region can increase the risk of a broad range of complex neuropsychiatric …
same genomic region can increase the risk of a broad range of complex neuropsychiatric …
Gene expression elucidates functional impact of polygenic risk for schizophrenia
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …