Background With the continuous emergence of new SARS-CoV-2 variants that feature
increased transmission and immune escape, there is an urgent demand for a better vaccine …

The emerging SARS-CoV-2 variants of concern (VOC) harbor mutations associated with
increasing transmission and immune escape, hence undermine the effectiveness of current …

Multiple SARS-CoV-2 variants are identified with higher rates of transmissibility or greater
disease severity. Particularly, recent emergence of Omicron variant with rapid human-to …

Developing a variant-specific vaccine has drawn great concern due to the considerably
altered antigenicity and immune evasion of the Omicron variant. Several recent studies have …

The major challenge in COVID‐19 vaccine effectiveness is immune escape by SARS‐CoV‐
2 variants. To overcome this, an Omicron‐specific messenger RNA (mRNA) vaccine was …

Introduction The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron
variant has rapidly spread around the globe. With a substantial number of mutations in its …

Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.
1/B. 1.1. 529) harboring up to 36 mutations in spike protein, the target of neutralizing …

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
in the Omicron lineage has resulted in diminished Coronavirus Disease 2019 (COVID-19) …

Abstract Two COVID-19 mRNA (of BNT162b2, mRNA-1273) and two adenovirus vector
vaccines (ChAdOx1 and Janssen) are licensed in Europe, but optimization of regime and …

SARS-CoV-2 variants of concern (VOCs) have shown resistance to vaccines targeting the
original virus strain. An mRNA vaccine encoding the spike protein of Omicron BA1 (BA1-S …