We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese
individuals and performed further transancestry meta-analyses with data from the Psychiatry …

Three-dimensional physical interactions within chromosomes dynamically regulate gene
expression in a tissue-specific manner,,. However, the 3D organization of chromosomes …

We interrogate the joint genetic architecture of 11 major psychiatric disorders at
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …

We report results from the Bipolar Exome (BipEx) collaboration analysis of whole-exome
sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We …

Numerous studies have examined gene expression profiles in post-mortem human brain
samples from individuals with schizophrenia compared with healthy controls, to gain insight …

Schizophrenia is a severe mental illness with a typically chronic course affecting nearly 1%
of the human population. It is generally accepted that genetic factors have an important …

Over the last decade, genome-wide association studies of psychiatric disorders have
identified numerous significant loci. Whereas these studies initially depended on cohorts …

Detailed knowledge of how diversity in the sequence of the human genome affects
phenotypic diversity depends on a comprehensive and reliable characterization of both …

The work conducted using genome-wide approaches during the past several years has
invigorated the field, and represents the dawn of molecular genetics of schizophrenia. The …

De novo mutations in protein-coding genes are a well-established cause of developmental
disorders. However, genes known to be associated with developmental disorders account …