The arsenic (+ 3 oxidation state) methyltransferase (As3mt) gene encodes a 43 kDa protein
that catalyzes methylation of inorganic arsenic. Altered expression of AS3MT in cultured …

Arsenic (+ 3 oxidation state) methyltransferase (As3mt) catalyzes formation of mono-, di-,
and tri-methylated metabolites of inorganic arsenic. Distribution and retention of arsenic …

Arsenic occurs naturally in the environment, and exists predominantly as inorganic arsenite
(As (III) and arsenate As (V)). Arsenic contamination of drinking water has long been …

Inorganic arsenic is enzymatically methylated; hence, its ingestion results in exposure to the
parent compound and various methylated arsenicals. Both experimental and …

Abstract Arsenic (+ 3 oxidation state) methyltransferase (As3mt) catalyzes methylation of
inorganic arsenic (iAs) producing a number of methylated arsenic metabolites. Although …

The metabolism of arsenicals, including their reduction and methylation has been
extensively studied, and both classical and novel pathways of arsenic methylation are …

Recent research of the metabolism and biological effects of arsenic has profoundly changed
our understanding of the role of metabolism in modulation of toxicity and carcinogenicity of …

A synthetic gene encoding human As (III) S-adenosylmethionine (SAM) methyltransferase
(hAS3MT) was expressed, and the purified enzyme was characterized. The synthetic …

Arsenic (+ 3 oxidation state) methyltransferase (AS3MT) is the key enzyme in the pathway
for methylation of arsenicals. A common polymorphism in the AS3MT gene that replaces a …

With the development of a rapid assay for arsenite methyltransferase (Zakharyanet al.,
1995), the specific activity of this critical enzyme for arsenite biotransformation was …