Background High-fat diet (HFD) is closely associated with the increased prevalence of
inflammatory bowel disease (IBD). Excessive gut microbial metabolite deoxycholic acid …

High-fat diet (HFD) leads to systemic low-grade inflammation, which has been involved in
the pathogenesis of diverse metabolic and inflammatory diseases. Colon is thought to be the …

Background The etiology of inflammatory bowel disease (IBD) remains unclear. However,
intestinal metabolism is known to be critical in the pathogenesis of IBD. Bile acid is one of …

Background A Western diet is a risk factor for the development of inflammatory bowel
disease (IBD). High levels of fecal deoxycholic acid (DCA) in response to a Western diet …

The relationship between the gut microbiota and the host immune system in the context of
the pathogenesis of inflammatory bowel disease (IBD) is unclear. A screen of human …

Deoxycholic acid (DCA) serves essential functions in both physiological and pathological
liver processes; nevertheless, the relationship among DCA, gut microbiota, and metabolism …

Commensal bacteria-derived metabolites are critical in regulating the host immune system.
Although the impact of gut microbiota-derived hydrophilic metabolites, such as short-chain …

High-fat diet (HFD) has long been recognized as risk factors for the development and
progression of ulcerative colitis (UC), but the exact mechanism remained elusive. Here, HFD …

Epidemiological studies have shown that fat rich western diet contributes to the high
incidence of inflammatory bowel disease (IBD). Moreover, accumulated data indicated that …

Clinical cases and animal experiments show that high-fat (HF) diet is involved in
inflammatory bowel disease (IBD), but the specific mechanism is not fully clear. A close …