Precise control and maintenance of population size is fundamental for organismal
development and homeostasis. The three cell types of the mammalian blastocyst are …

During embryonic development and tissue homeostasis, reproducible proportions of
differentiated cell types are specified from populations of multipotent precursor cells …

Intercellular communication is essential to coordinate the behaviour of individual cells
during organismal development. The preimplantation mammalian embryo is a paradigm of …

Preimplantation development in mammals encompasses a period from fertilization to
implantation and results in formation of a blastocyst composed of three distinct cell lineages …

Embryonic development is a self-organised process during which cells divide, interact,
change fate according to a complex gene regulatory network and organise themselves in a …

Understanding how individual cells make fate decisions that lead to the faithful formation
and homeostatic maintenance of tissues is a fundamental goal of contemporary …

Early mammalian development is both highly regulative and self-organizing. It involves the
interplay of cell position, predetermined gene regulatory networks, and environmental …

Correct and timely lineage decisions are critical for normal embryonic development and
homeostasis of adult tissues. Therefore, the search for fundamental principles that underlie …

During development, interactions between transcription factors control the specification of
different cell fates. The regulatory networks of genetic interactions often exhibit multiple …

During embryonic development, diffusible signaling molecules called morphogens are
thought to determine cell fates in a concentration-dependent way. Yet, in mammalian …