Visible-light-induced intramolecular radical cascade of α-bromo-N-benzyl-alkylamides: A new strategy to synthesize tetracyclic N-fused indolo [2, 1-a] isoquinolin-6 (5 …

X Gao, C Li, Y Yuan, X Xie, Z Zhang - Organic & Biomolecular …, 2020 - pubs.rsc.org
Polycyclic indole scaffolds are ubiquitous in pharmaceuticals and natural products and in
materials science. Here, we present a visible-light-initiated intramolecular aryl migration …

Intramolecular cascade cyclization via photogenerated N-amidyl radicals toward isoindolin-1-one/3, 4-dihydroisoquinolin-1 (2 H)-one fused oxazinane

YX He, K Hu, Y Ran, ZY Lei, S Geng… - Organic Chemistry …, 2023 - pubs.rsc.org
Based on the importance of the two classes of nitrogen-containing heterocyclic structures,
isoindolinones and isoquinolinones, herein, through intramolecular cascade cyclization via …

Synthesis of indolo [2, 1-α] isoquinoline derivatives via metal-free radical cascade cyclization

XY Hu, HF Xu, Q Chen, YL Pan, JZ Chen - Organic & Biomolecular …, 2021 - pubs.rsc.org
In the present studies, we describe a convenient and efficient protocol for the synthesis of
the indolo [2, 1-α] isoquinoline core structure through the reaction of 2-aryl-N-acryloyl …

Synthesis of indolo [2, 1-a] isoquinoline derivatives via visible-light-induced radical cascade cyclization reactions

YL Wei, JQ Chen, B Sun, PF Xu - Chemical Communications, 2019 - pubs.rsc.org
We describe a photocatalyzed transformation for the synthesis of the indolo [2, 1-a]
isoquinoline core structure. This redox neutral reaction features mild reaction conditions and …

Visible-light-induced acylation/cyclization of active alkenes: facile access to acylated isoquinolinones

Y Guo, PF Huang, Y Liu, BH He - Organic & Biomolecular Chemistry, 2022 - pubs.rsc.org
Nitrogen heterocycles, especially polycyclic compounds, are significant skeletons in
valuable molecules. Herein, we developed an efficient and practical visible-light-induced …

Synthesis of arylsulfonyl-substituted indolo [2, 1-a] isoquinolin-6 (5H)-one derivatives via a TBAI-catalyzed radical cascade cyclization

S Zhai, S Qiu, S Yang, B Hua, Y Niu, C Han, Y Yu… - Chinese Chemical …, 2022 - Elsevier
We have developed a metal-free radical cascade reaction of N-substituted 2-aryl indoles
with readily available sulfonyl hydrazides for the rapid construction of arylsulfonyl …

Accessing pyrrolo [1, 2-a] indole derivatives via visible-light-induced dearomatizative cyclization of indoles

Z Liu, X Ji, L Duan, GJ Deng, H Huang - Chemical Communications, 2024 - pubs.rsc.org
Pyrrolo [1, 2-a] indoles are structurally important scaffolds in many natural products and
bioactive compounds. Herein, we report a novel synthetic method for pyrrolo [1, 2-a] indole …

Visible light-induced N-radical 5-exo/6-endo cyclization of alkenyl amides: facile access to isoindolinones/isoquinolinones

ZY Lei, K Hu, YX He, S Geng, LN Chen… - Organic & …, 2022 - pubs.rsc.org
An efficient N-centered radical intramolecular cyclization reaction of alkenyl amides induced
by visible light was described. In this process, an alkenyl amide underwent 5-exo/6-endo …

Cascade cyclization for the synthesis of indolo [2, 1-α] isoquinoline derivatives via visible-light-induced halogen-atom-transfer (XAT) and hydrogen-atom-transfer (HAT …

N Ma, L Guo, ZJ Shen, D Qi, C Yang… - Organic & Biomolecular …, 2022 - pubs.rsc.org
A transition metal-free photoredox cascade cyclization is herein reported. In this protocol,
sustainable visible light was used as the energy source and organic light-emitting molecule …

Copper-catalyzed amino radical tandem cyclization toward the synthesis of indolo-[2, 1-a] isoquinolines

ML Liu, JL Wang, XS Li, WH Sun, XY Liu - Organic Chemistry Frontiers, 2022 - pubs.rsc.org
We report a convenient process for synthesizing indolo-[2, 1-a] isoquinoline tetracyclic
skeletons in one pot via a low-cost copper-catalyzed tandem amino radical cyclization, in …