Challenges for drug repurposing in the COVID-19 pandemic era

J Sultana, S Crisafulli, F Gabbay, E Lynn… - Frontiers in …, 2020 - frontiersin.org
The coronavirus disease (COVID-19) pandemic has affected an estimated 16 million
persons and caused 0.6 million deaths worldwide by September 2020. The pandemic has …

Therapeutic effectiveness and safety of repurposing drugs for the treatment of COVID-19: position standing in 2021

S Alam, TB Kamal, MMR Sarker, JR Zhou… - Frontiers in …, 2021 - frontiersin.org
COVID-19, transmitted by SARS-CoV-2, is one of the most serious pandemic situations in
the history of mankind, and has already infected a huge population across the globe. This …

Drug repurposing for COVID-19: Approaches, challenges and promising candidates

YL Ng, CK Salim, JJH Chu - Pharmacology & therapeutics, 2021 - Elsevier
Traditional drug development and discovery has not kept pace with threats from emerging
and re-emerging diseases such as Ebola virus, MERS-CoV and more recently, SARS-CoV …

Combating devastating COVID-19 by drug repurposing

AY Pawar - International Journal of Antimicrobial Agents, 2020 - Elsevier
Despite advances in drug discovery, viral infections remain a major challenge for scientists
across the globe. The recent pandemic of COVID-19 (coronavirus disease 2019), caused by …

Utilizing drug repurposing against COVID-19–efficacy, limitations, and challenges

V Parvathaneni, V Gupta - Life sciences, 2020 - Elsevier
The recent outbreak of Coronavirus disease (COVID-19), first in Eastern Asia and then
essentially across the world has been declared a pandemic by the WHO. COVID-19 is …

Repurposing drugs for the management of COVID-19

J Cusinato, Y Cau, AM Calvani… - Expert opinion on …, 2021 - Taylor & Francis
Introduction: The coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 represents
a serious health issue worldwide, with more than 61 million cases and more than 1.4 million …

Drug repurposing strategies for COVID-19

SL Senanayake - Future Drug Discovery, 2020 - Taylor & Francis
COVID-19 has now been declared a pandemic and new treatments are urgently needed as
we enter a phase beyond containment. Developing new drugs from scratch is a lengthy …

Drug repurposing for COVID-19: A review and a novel strategy to identify new targets and potential drug candidates

L Rodrigues, R Bento Cunha, T Vassilevskaia… - Molecules, 2022 - mdpi.com
In December 2019, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2), the causative agent of coronavirus disease 2019 (COVID-19) was first identified in the …

[HTML][HTML] Boosting the arsenal against COVID-19 through computational drug repurposing

G Ciliberto, L Cardone - Drug discovery today, 2020 - ncbi.nlm.nih.gov
The coronavirus disease 2019 (COVID-19) world health emergency is calling scientists for
unprecedented, huge investigation efforts to urgently answer key questions: what is the …

[HTML][HTML] Drug repurposing in COVID-19: a review with past, present and future

K Srivastava, MK Singh - Metabolism Open, 2021 - Elsevier
The coronavirus SARS-CoV-2 which causes the COVID-19 disease is a global public health
emergency. Coronavirus are single-stranded positive-sense RNA viruses and their genome …