[HTML][HTML] Mammary gland development from a single cell 'omics view

AJ Twigger, WT Khaled - Seminars in Cell & Developmental Biology, 2021 - Elsevier
Understanding the complexity and heterogeneity of mammary cell subpopulations is vital to
delineate the mechanisms behind breast cancer development, progression and prevention …

Characterization of gene expression signatures for the identification of cellular heterogeneity in the developing mammary gland

S Henry, MC Trousdell, SL Cyrill, Y Zhao… - Journal of Mammary …, 2021 - Springer
The developing mammary gland depends on several transcription-dependent networks to
define cellular identities and differentiation trajectories. Recent technological advancements …

[HTML][HTML] Stem cells and the differentiation hierarchy in mammary gland development

NY Fu, E Nolan, GJ Lindeman… - Physiological …, 2020 - journals.physiology.org
The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …

Neutral lineage tracing of proliferative embryonic and adult mammary stem/progenitor cells

B Lloyd-Lewis, FM Davis, OB Harris… - …, 2018 - journals.biologists.com
Mammary gland development occurs over multiple phases, beginning in the mammalian
embryo and continuing throughout reproductive life. The remarkable morphogenetic …

Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate

H Kendrick, JL Regan, FA Magnay, A Grigoriadis… - BMC genomics, 2008 - Springer
Background Understanding the molecular control of cell lineages and fate determination in
complex tissues is key to not only understanding the developmental biology and cellular …

Cellular plasticity of mammary epithelial cells underlies heterogeneity of breast cancer

V Rodilla, S Fre - Biomedicines, 2018 - mdpi.com
The hierarchical relationships between stem cells, lineage-committed progenitors, and
differentiated cells remain unclear in several tissues, due to a high degree of cell plasticity …

Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis

JE Visvader - Genes & development, 2009 - genesdev.cshlp.org
The epithelium of the mammary gland exists in a highly dynamic state, undergoing dramatic
morphogenetic changes during puberty, pregnancy, lactation, and regression. The recent …

Mammary stem cells: angels or demons in mammary gland?

X Chen, Q Liu, E Song - Signal Transduction and Targeted Therapy, 2017 - nature.com
A highly dynamic development process exits within the epithelia of mammary gland,
featuring morphogenetic variation during puberty, pregnancy, lactation, and regression. The …

Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment

O Wansbury, A Mackay, N Kogata, C Mitsopoulos… - Breast Cancer …, 2011 - Springer
Introduction The mammary primordium forms during embryogenesis as a result of inductive
interactions between its constitutive tissues, the mesenchyme and epithelium, and …

Mammary development in the embryo and adult: new insights into the journey of morphogenesis and commitment

CJ Watson, WT Khaled - Development, 2020 - journals.biologists.com
The mammary gland is a unique tissue and the defining feature of the class Mammalia. It is a
late-evolving epidermal appendage that has the primary function of providing nutrition for …