Metabolic tumor burden: a new promising way to reach precise personalized therapy in PDAC

J Xiang, L Liu, W Wang, H Xu, C Wu, J Xu, C Liu… - Cancer letters, 2015 - Elsevier
Pancreatic cancer is currently one of the deadliest solid malignancies and pancreatic ductal
adenocarcinoma (PDAC) is the most common type of pancreatic cancer. In the past decade …

Metabolomics approaches in pancreatic adenocarcinoma: tumor metabolism profiling predicts clinical outcome of patients

S Battini, F Faitot, A Imperiale, AE Cicek, C Heimburger… - BMC medicine, 2017 - Springer
Abstract Background Pancreatic adenocarcinomas (PAs) have very poor prognoses even
when surgery is possible. Currently, there are no tissular biomarkers to predict long-term …

Metabolomic profiling of pancreatic adenocarcinoma reveals key features driving clinical outcome and drug resistance

A El Kaoutari, NA Fraunhoffer, O Hoare… - …, 2021 - thelancet.com
Background Although significant advances have been made recently to characterize the
biology of pancreatic ductal adenocarcinoma (PDAC), more efforts are needed to improve …

Discovery of pancreatic adenocarcinoma biomarkers by untargeted metabolomics

A Martín-Blázquez, C Jiménez-Luna, C Díaz… - Cancers, 2020 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal
cancers, with a 5-year survival rate of less than 5%. In fact, complete surgical resection …

Metabolomic analyses redefine the biological classification of pancreatic cancer and correlate with clinical outcomes

P Guo, T Teng, W Liu, Y Fang, B Wei… - … Journal of Cancer, 2022 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is characterized by high heterogeneity, and the
postoperative prognosis of different patients often varies greatly. Therefore, the classification …

Meta-analysis reveals both the promises and the challenges of clinical metabolomics

HE Roth, R Powers - Cancers, 2022 - mdpi.com
Simple Summary A highly desirable approach to diagnose a human disease quickly and
easily is to identify a chemical, protein, or antibody in a biofluid like blood or urine that is …

Evaluating metabolite-based biomarkers for early diagnosis of pancreatic cancer: a systematic review

G Perazzoli, OM García-Valdeavero, M Pena, J Prados… - Metabolites, 2023 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with five-year
survival rates around 10%. The only curative option remains complete surgical resection, but …

Biomarkers for pancreatic cancer based on tissue and serum metabolomics analysis in a multicenter study

R Zhao, S Ren, C Li, K Guo, Z Lu, L Tian, J He… - Cancer …, 2023 - Wiley Online Library
Background Early detection of pancreatic ductal adenocarcinoma (PDAC) may improve the
prognosis of patients. This study was to identify metabolic features of PDAC and to discover …

Advances in pancreatic cancer: The role of metabolomics

V Nguyen, S Hurton, S Ayloo… - JOP. Journal of the …, 2015 - serena.unina.it
Metabolomics is an emerging scientific field focusing on compounds, also known as
metabolomes that are produced by biologic systems. Metabolomes represent phenotypic …

Plasma metabolomics predicts chemotherapy response in advanced pancreatic cancer

H Muranaka, A Hendifar, A Osipov, N Moshayedi… - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic cancer is a clinically heterogeneous disease, and treatment
leads to different outcomes for people with similar diagnoses. Identifying patients who may …