Robust validation and comprehensive analysis of a novel signature derived from crucial metabolic pathways of pancreatic ductal adenocarcinoma

W Gu, S Mo, Y Wang, R Kawabata-Iwakawa, W Zhang… - Cancers, 2022 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) has a high mortality rate and a
poor prognosis. To solve the above limitations of multiomics studies of metabolism in PDAC …

[PDF][PDF] The intricate metabolism of pancreatic cancers

F Camelo, A Le - The Heterogeneity of Cancer Metabolism, 2021 - library.oapen.org
Currently, approximately 95% of pancreatic cancers are pancreatic ductal adenocarcinomas
(PDAC), which are the most aggressive form and the fourth leading cause of cancer death …

Metabolic phenotypes in pancreatic cancer

M Yu, Q Zhou, Y Zhou, Z Fu, L Tan, X Ye, B Zeng… - PLoS …, 2015 - journals.plos.org
Introduction The aim of present study was to profile the glucose-dependent and glutamine-
dependent metabolism in pancreatic cancer. Methods We performed Immunohistochemical …

Analytical metabolomics-based approaches to pancreatic cancer

IM Di Gangi, U Vrhovsek, V Pazienza… - TrAC Trends in Analytical …, 2014 - Elsevier
We provide a comprehensive review of the analytical technologies applied in pancreatic
cancer (PC) research, investigating tumor-associated metabolites identified as possible new …

[HTML][HTML] Metabolic profiles are principally different between cancers of the liver, pancreas and breast

A Budhu, A Terunuma, G Zhang… - … journal of biological …, 2014 - ncbi.nlm.nih.gov
Molecular profiling of primary tumors may facilitate the classification of patients with cancer
into more homogenous biological groups to aid clinical management. Metabolomic profiling …

Untargeted LC-HRMS-based metabolomics for searching new biomarkers of pancreatic ductal adenocarcinoma: A pilot study

S Rios Peces, C Diaz Navarro… - … Life Sciences R&D, 2017 - journals.sagepub.com
Pancreatic ductal adenocarcinoma is one of the most lethal tumors since it is usually
detected at an advanced stage in which surgery and/or current chemotherapy have limited …

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

A Daemen, D Peterson, N Sahu… - Proceedings of the …, 2015 - National Acad Sciences
Although targeting cancer metabolism is a promising therapeutic strategy, clinical success
will depend on an accurate diagnostic identification of tumor subtypes with specific …

Plasma metabolome profiling identifies metabolic subtypes of pancreatic ductal adenocarcinoma

UM Mahajan, A Alnatsha, Q Li, B Oehrle, FU Weiss… - Cells, 2021 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Developing
biomarkers for early detection and chemotherapeutic response prediction is crucial to …

A unique urinary metabolomic signature for the detection of pancreatic ductal adenocarcinoma

S Sahni, AR Pandya, WJ Hadden… - … Journal of Cancer, 2021 - Wiley Online Library
Our study aimed to identify a urinary metabolite panel for the detection/diagnosis of
pancreatic ductal adenocarcinoma (PDAC). PDAC continues to have poor survival …

A metabolism-relevant signature as a predictor for prognosis and therapeutic response in pancreatic cancer

Q Chen, N Pu, H Yin, J Zhang, G Zhao… - Experimental …, 2022 - journals.sagepub.com
Although several altered metabolic genes have been identified to be involved in the
tumorigenesis and advance of pancreatic cancer (PC), their prognostic values remained …