Current state of “omics” biomarkers in pancreatic cancer

B Turanli, E Yildirim, G Gulfidan, KY Arga… - Journal of Personalized …, 2021 - mdpi.com
Pancreatic cancer is one of the most fatal malignancies and the seventh leading cause of
cancer-related deaths related to late diagnosis, poor survival rates, and high incidence of …

A novel serum metabolomic profile for the differential diagnosis of distal cholangiocarcinoma and pancreatic ductal adenocarcinoma

RIR Macias, L Muñoz-Bellvís, A Sánchez-Martín… - Cancers, 2020 - mdpi.com
The diagnosis of adenocarcinomas located in the pancreas head, ie, distal
cholangiocarcinoma (dCCA) and pancreatic ductal adenocarcinoma (PDAC), constitutes a …

Treatment optimization of locally advanced and metastatic pancreatic cancer

AG Barros, CF Pulido, M Machado… - International …, 2021 - spandidos-publications.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant tumor types,
being the sixth leading cause of mortality worldwide and the fourth in Europe. Globally, it has …

Metabolomic prediction of treatment outcome in pancreatic ductal adenocarcinoma patients receiving gemcitabine

LC Phua, S Goh, DWM Tai, WQ Leow… - Cancer Chemotherapy …, 2018 - Springer
Purpose Resistance to gemcitabine remains a key challenge in the treatment of pancreatic
ductal adenocarcinoma (PDAC), necessitating the constant search for effective strategies for …

Single-cell transcriptome reveals the metabolic and clinical features of a highly malignant cell subpopulation in pancreatic ductal adenocarcinoma

Y Fang, S Pei, K Huang, F Xu, G Xiang… - Frontiers in Cell and …, 2022 - frontiersin.org
Background: Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with a high
mortality rate. PDAC exhibits significant heterogeneity as well as alterations in metabolic …

Lipid metabolic reprogramming extends beyond histologic tumor demarcations in operable human pancreatic cancer

J Pirhonen, Á Szkalisity, J Hagström, Y Kim, E Migh… - Cancer Research, 2022 - AACR
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest malignancies and
potentially curable only with radical surgical resection at early stages. The tumor …

Comprehensive mass spectrometry based metabolic profiling of blood plasma reveals potent discriminatory classifiers of pancreatic cancer

S Urayama, W Zou, K Brooks… - … in Mass Spectrometry …, 2010 - Wiley Online Library
Poor outcome of pancreatic cancer necessitates development of an early diagnostic method
to reduce mortality. No reliable early diagnostic test for pancreatic cancer detection has …

Metabolic pathways as a novel landscape in pancreatic ductal adenocarcinoma

A Ali, U Chianese, C Papulino, A Toraldo, MEA Abakar… - Cancers, 2022 - mdpi.com
Simple Summary The survival of organic systems is dependent on metabolic conditions,
necessary for the proper functioning of all biological processes. Cancer takes advantage of …

Metabolomics at the tumor microenvironment interface: Decoding cellular conversations

N Berrell, H Sadeghirad, T Blick… - Medicinal Research …, 2024 - Wiley Online Library
Cancer heterogeneity remains a significant challenge for effective cancer treatments. Altered
energetics is one of the hallmarks of cancer and influences tumor growth and drug …

Precision medicine approaches in metabolic disorders and target organ damage: where are we now, and where are we going?

A Lonardo, C Byrne, G Targher - Metabolism and Target Organ …, 2021 - eprints.soton.ac.uk
In this review, we discuss selected topics which are relevant to implementing precision
medicine in metabolic disorders. Personalization of diet and exercise may help in preventing …