[HTML][HTML] Role of neutrophils, platelets, and extracellular vesicles and their interactions in COVID‐19‐associated thrombopathy

A Caillon, A Trimaille, J Favre, L Jesel, O Morel… - Journal of Thrombosis …, 2022 - Elsevier
The COVID‐19 pandemic extended all around the world causing millions of deaths. In
addition to acute respiratory distress syndrome, many patients with severe COVID‐19 …

Activated platelets and platelet-derived extracellular vesicles mediate COVID-19-associated immunothrombosis

M Ebeyer-Masotta, T Eichhorn, R Weiss… - Frontiers in Cell and …, 2022 - frontiersin.org
Activated platelets and platelet-derived extracellular vesicles (EVs) have emerged as central
players in thromboembolic complications associated with severe coronavirus disease 2019 …

Immunothrombosis in COVID-19: implications of neutrophil extracellular traps

B Bautista-Becerril, R Campi-Caballero… - Biomolecules, 2021 - mdpi.com
SARS-CoV-2 is a member of the family of coronaviruses associated with severe outbreaks of
respiratory diseases in recent decades and is the causative agent of the COVID-19 …

Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

P Skendros, A Mitsios… - The Journal of …, 2020 - Am Soc Clin Investig
Emerging data indicate that complement and neutrophils contribute to the maladaptive
immune response that fuels hyperinflammation and thrombotic microangiopathy, thereby …

The interplay between neutrophils, complement, and microthrombi in COVID-19

Y Zuo, Y Kanthi, JS Knight, AHJ Kim - Best practice & research Clinical …, 2021 - Elsevier
As of the end of 2020, coronavirus disease 2019 (COVID-19) remains a global healthcare
challenge with alarming death tolls. In the absence of targeted therapies, supportive care …

Pathophysiological mechanisms of thrombosis in acute and long COVID-19

H Jing, X Wu, M Xiang, L Liu, VA Novakovic… - Frontiers in …, 2022 - frontiersin.org
COVID-19 patients have a high incidence of thrombosis, and thromboembolic complications
are associated with severe COVID-19 and high mortality. COVID-19 disease is associated …

Patients with COVID-19: in the dark-NETs of neutrophils

M Ackermann, HJ Anders, R Bilyy, GL Bowlin… - Cell Death & …, 2021 - nature.com
SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs,
occasionally causing death. Until effective vaccines are developed to curb the pandemic, it …

Platelets:" multiple choice" effectors in the immune response and their implication in COVID‐19 thromboinflammatory process

R Rolla, C Puricelli, A Bertoni, E Boggio… - International Journal …, 2021 - Wiley Online Library
Although platelets are traditionally recognized for their central role in hemostasis, the
presence of chemotactic factors, chemokines, adhesion molecules, and costimulatory …

Thromboinflammation in long COVID—the elusive key to postinfection sequelae?

L Nicolai, R Kaiser, K Stark - Journal of Thrombosis and Haemostasis, 2023 - Elsevier
Long COVID is a public health emergency affecting millions of people worldwide,
characterized by heterogeneous symptoms across multiple organ systems. Here, we discuss …

Neutrophil-platelet interactions as novel treatment targets in cardiovascular disease

R Kaiser, R Escaig, J Erber, L Nicolai - Frontiers in cardiovascular …, 2022 - frontiersin.org
Neutrophils and platelets are among the most abundant cell types in peripheral blood and
characterized by high plasticity and a readily available reservoir of surface proteins and …