Background Noroviruses are the leading cause of viral gastroenteritis. Because a suitable in
vitro culture system for the human virus has yet to be developed, many basic details of the …

Noroviruses (NVs) are recognized as a major cause of nonbacterial gastroenteritis in
humans. Studies of the human NVs continue to be hampered by the inability to propagate …

Human norovirus is the leading cause of acute gastroenteritis worldwide, however despite
the significance of this pathogen, we have a limited understanding of how noroviruses cause …

Investigations into human norovirus infection, replication and pathogenesis, as well as the
development of potential antiviral agents, have been restricted by the lack of a cell culture …

Human norovirus (HNoV) is the leading cause of acute gastroenteritis and is spread by fecal
shedding that can often persist for weeks to months after the resolution of symptoms …

Gastroenteritis caused by bacterial and viral pathogens constitutes a major public health
threat in the United States accounting for 35% of hospitalizations. In particular, Salmonella …

The human norovirus (HuNV)-encoded nucleoside-triphosphatase (NTPase) is a
multifunctional protein critically involved in viral replication and pathogenesis. Previously …

Calicivirus infection causes intrinsic apoptosis, leading to viral propagation in the host.
During murine norovirus infection, a reduction in the anti-apoptotic protein survivin has been …

The norovirus NS6 protease is a key target for anti-viral drug development. Noroviruses
encode a 2200 amino acid polyprotein which is cleaved by this critical protease at five …

Human norovirus infects humans through the consumption of contaminated food, contact
with the excrement or vomit of an infected person and through airborne droplets that scatter …