Bone is a highly vascularized tissue, in which vascularization and mineralization are
concurrent processes during skeletal development. Indeed, both components should be …

Vascularization is a fundamental prerequisite for large bone construct development and
remains one of the main challenges of bone tissue engineering. Our current study presents …

Tissue engineering provides unique opportunities for regenerating diseased or damaged
tissues using cells obtained from tissue biopsies. Tissue engineered grafts can also be used …

The generation of functional, vascularized tissues is a key challenge for both tissue
engineering applications and the development of advanced in vitro models analyzing …

To engineer tissues with clinically relevant dimensions, one must overcome the challenge of
rapidly creating functional blood vessels to supply cells with oxygen and nutrients and to …

Aim: We aimed to establish a 3D vascularized in vitro bone remodeling model. Materials &
methods: Human umbilical endothelial cells (HUVECs), bone marrow mesenchymal stem …

A functional vascular supply is a key component of any large-scale tissue, providing support
for the metabolic needs of tissue-remodeling cells. Although well-studied strategies exist to …

The development of sufficient vascular networks is crucial for the successful fabrication of
tissue constructs for regenerative medicine, as vascularization is essential to perform the …

The crosstalk between osteoblasts and endothelial cells is critical for bone vascularization
and regeneration. Here, we used a coaxial 3D bioprinting method to directly print an osteon …

Vascularization in bone tissues is essential for the distribution of nutrients and oxygen, as
well as the removal of waste products. Fabrication of tissue-engineered bone constructs with …