Allele frequency matching between SNPs reveals an excess of linkage disequilibrium in genic regions of the human genome
Significant interest has emerged in mapping genetic susceptibility for complex traits through
whole-genome association studies. These studies rely on the extent of association, ie …
whole-genome association studies. These studies rely on the extent of association, ie …
A genomic background based method for association analysis in related individuals
Background Feasibility of genotyping of hundreds and thousands of single nucleotide
polymorphisms (SNPs) in thousands of study subjects have triggered the need for fast …
polymorphisms (SNPs) in thousands of study subjects have triggered the need for fast …
Worldwide population differentiation at disease-associated SNPs
Background Recent genome-wide association (GWA) studies have provided compelling
evidence of association between genetic variants and common complex diseases. These …
evidence of association between genetic variants and common complex diseases. These …
GPA: a statistical approach to prioritizing GWAS results by integrating pleiotropy and annotation
Results from Genome-Wide Association Studies (GWAS) have shown that complex diseases
are often affected by many genetic variants with small or moderate effects. Identifications of …
are often affected by many genetic variants with small or moderate effects. Identifications of …
MultiPhen: joint model of multiple phenotypes can increase discovery in GWAS
The genome-wide association study (GWAS) approach has discovered hundreds of genetic
variants associated with diseases and quantitative traits. However, despite clinical overlap …
variants associated with diseases and quantitative traits. However, despite clinical overlap …
Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases
Many disease-susceptible SNPs exhibit significant disparity in ancestral and derived allele
frequencies across worldwide populations. While previous studies have examined …
frequencies across worldwide populations. While previous studies have examined …
[HTML][HTML] Reaching the end-game for GWAS: machine learning approaches for the prioritization of complex disease loci
Genome-wide association studies (GWAS) have revealed thousands of genetic loci that
underpin the complex biology of many human traits. However, the strength of GWAS–the …
underpin the complex biology of many human traits. However, the strength of GWAS–the …
Benefits and limitations of genome-wide association studies
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
Orienting the causal relationship between imprecisely measured traits using GWAS summary data
Inference about the causal structure that induces correlations between two traits can be
achieved by combining genetic associations with a mediation-based approach, as is done in …
achieved by combining genetic associations with a mediation-based approach, as is done in …
Genome-wide association studies in diverse populations
NA Rosenberg, L Huang, EM Jewett… - Nature Reviews …, 2010 - nature.com
Genome-wide association (GWA) studies have identified a large number of SNPs
associated with disease phenotypes. As most GWA studies have been performed in …
associated with disease phenotypes. As most GWA studies have been performed in …