[HTML][HTML] Further improvements to linear mixed models for genome-wide association studies
We examine improvements to the linear mixed model (LMM) that better correct for
population structure and family relatedness in genome-wide association studies (GWAS) …
population structure and family relatedness in genome-wide association studies (GWAS) …
Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification
Although the cohort-level accuracy of polygenic risk scores (PRSs)—estimates of genetic
value at the individual level—has been widely assessed, uncertainty in PRSs remains …
value at the individual level—has been widely assessed, uncertainty in PRSs remains …
Comparison of methods for estimating genetic correlation between complex traits using GWAS summary statistics
Genetic correlation is the correlation of phenotypic effects by genetic variants across the
genome on two phenotypes. It is an informative metric to quantify the overall genetic …
genome on two phenotypes. It is an informative metric to quantify the overall genetic …
Transformation of summary statistics from linear mixed model association on all-or-none traits to odds ratio
Genome-wide association studies (GWAS) have identified thousands of loci that are robustly
associated with complex diseases. The use of linear mixed model (LMM) methodology for …
associated with complex diseases. The use of linear mixed model (LMM) methodology for …
[HTML][HTML] Transferability of genetic risk scores in African populations
AB Kamiza, SM Toure, M Vujkovic, T Machipisa… - Nature Medicine, 2022 - nature.com
The poor transferability of genetic risk scores (GRSs) derived from European ancestry data
in diverse populations is a cause of concern. We set out to evaluate whether GRSs derived …
in diverse populations is a cause of concern. We set out to evaluate whether GRSs derived …
A new method for multiancestry polygenic prediction improves performance across diverse populations
Polygenic risk scores (PRSs) increasingly predict complex traits; however, suboptimal
performance in non-European populations raise concerns about clinical applications and …
performance in non-European populations raise concerns about clinical applications and …
Improving reporting standards for polygenic scores in risk prediction studies
H Wand, SA Lambert, C Tamburro, MA Iacocca… - Nature, 2021 - nature.com
Polygenic risk scores (PRSs), which often aggregate results from genome-wide association
studies, can bridge the gap between initial discovery efforts and clinical applications for the …
studies, can bridge the gap between initial discovery efforts and clinical applications for the …
[HTML][HTML] All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs
Recent results indicate that genome-wide association studies (GWAS) have the potential to
explain much of the heritability of common complex phenotypes, but methods are lacking to …
explain much of the heritability of common complex phenotypes, but methods are lacking to …
Genome-wide complex trait analysis (GCTA): methods, data analyses, and interpretations
Estimating genetic variance is traditionally performed using pedigree analysis. Using high-
throughput DNA marker data measured across the entire genome it is now possible to …
throughput DNA marker data measured across the entire genome it is now possible to …
[HTML][HTML] The impact of phenotypic and genetic heterogeneity on results of genome wide association studies of complex diseases
Phenotypic misclassification (between cases) has been shown to reduce the power to detect
association in genetic studies. However, it is conceivable that complex traits are …
association in genetic studies. However, it is conceivable that complex traits are …