JAK–STAT pathway activation in COPD

L Yew-Booth, MA Birrell, MS Lau… - European …, 2015 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is an inflammatory disease of the lung, most
commonly resulting from cigarette smoke exposure, characterised by a largely irreversible …

Role of JAK/STAT in interstitial lung diseases; molecular and cellular mechanisms

P Montero, J Milara, I Roger, J Cortijo - International journal of molecular …, 2021 - mdpi.com
Interstitial lung diseases (ILDs) comprise different fibrotic lung disorders characterized by
cellular proliferation, interstitial inflammation, and fibrosis. The JAK/STAT molecular pathway …

The JAK2 pathway is activated in idiopathic pulmonary fibrosis

J Milara, G Hernandez, B Ballester, A Morell, I Roger… - Respiratory …, 2018 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal
fibrotic disorder, with no curative therapies. The signal transducer and activator of …

Cigarette smoke exposure as a model of inflammation associated with COPD

S Eltom, C Stevenson, MA Birrell - Current protocols in …, 2013 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow
limitation resulting from inflammation‐driven pathologies in the lungs that are a …

Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine

CA Brandsma, M Van den Berge… - The Journal of …, 2020 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high
personal and societal burden. Exposure to toxic particles and gases, including cigarette …

Emerging anti-inflammatory strategies for COPD

M Cazzola, CP Page, L Calzetta… - European Respiratory …, 2012 - Eur Respiratory Soc
The hallmark of chronic obstructive pulmonary disease (COPD) is an enhanced or abnormal
inflammatory immune response of the lungs to inhaled particles and gases, usually from …

Impacts of peroxisome proliferator-activated receptor-γ activation on cigarette smoke-induced exacerbated response to bacteria

MC Morissette, P Shen, D Thayaparan… - European Respiratory …, 2015 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is characterised by a state of chronic
pulmonary inflammation punctuated by microbial exacerbations. Despite advances in …

COPD disease progression and airway inflammation: uncoupled by smoking cessation

PW Ind - European Respiratory Journal, 2005 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is an important cause of morbidity, mortality
and socioeconomic burden, and its prevalence continues to increase. It is expected to rise …

Janus kinase/signal transducers and activator of transcription (JAK/STAT) and its role in Lung inflammatory disease

M Purohit, G Gupta, O Afzal, ASA Altamimi… - Chemico-biological …, 2023 - Elsevier
A key signaling channel for the signal transduction of several crucial cytokines implicated in
sepsis is the JAK/STAT system. Once cytokines attach to the proper receptors, JAK kinases …

[HTML][HTML] Pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke

M Hikichi, K Mizumura, S Maruoka… - Journal of thoracic …, 2019 - ncbi.nlm.nih.gov
Chronic obstructive pulmonary disease (COPD) is a common respiratory disease that is
characterized by functional and structural alterations primarily caused by long-term …