Interleukin-6 receptor blocking with intravenous tocilizumab in COVID-19 severe acute respiratory distress syndrome: A retrospective case-control survival analysis of …

LM Canziani, S Trovati, E Brunetta, A Testa… - Journal of …, 2020 - Elsevier
In cases of COVID-19 acute respiratory distress syndrome, an excessive host inflammatory
response has been reported, with elevated serum interleukin-6 levels. In this multicenter …

Tocilizumab in hospitalized patients with severe Covid-19 pneumonia

IO Rosas, N Bräu, M Waters, RC Go… - … England Journal of …, 2021 - Mass Medical Soc
Abstract Background Coronavirus disease 2019 (Covid-19) is associated with immune
dysregulation and hyperinflammation, including elevated interleukin-6 levels. The use of …

Tocilizumab in patients with severe COVID‐19: A single‐center observational analysis

JP Knorr, V Colomy, CM Mauriello… - Journal of Medical …, 2020 - Wiley Online Library
Patients with coronavirus disease 2019 (COVID‐19) may develop severe respiratory
distress, thought to be mediated by cytokine release. Elevated proinflammatory markers …

Tocilizumab in patients with severe COVID-19: a retrospective cohort study

G Guaraldi, M Meschiari, A Cozzi-Lepri… - The Lancet …, 2020 - thelancet.com
Background No therapy is approved for COVID-19 pneumonia. The aim of this study was to
assess the role of tocilizumab in reducing the risk of invasive mechanical ventilation and …

[HTML][HTML] Temporal clinical and laboratory response to interleukin-6 receptor blockade with tocilizumab in 89 hospitalized patients with COVID-19 pneumonia

DS Fomina, AL Mar'yana, IP Beloglazova… - Pathogens and …, 2020 - ncbi.nlm.nih.gov
Background: Pandemic COVID-19 pneumonia due to SARS-2 is an important cause of
morbidity and mortality. Emerging evidence links poor outcomes to an inflammatory cytokine …

[HTML][HTML] Repurposed tocilizumab in patients with severe COVID-19

J Tian, M Zhang, M Jin, F Zhang, Q Chu… - The Journal of …, 2021 - journals.aai.org
The coronavirus disease 2019 (COVID-19) has caused a global pandemic, resulting in
considerable morbidity and mortality. Tocilizumab, an inhibitor of IL-6, has been widely …

Clinical outcomes in COVID‐19 patients treated with tocilizumab: an individual patient data systematic review

D Antwi‐Amoabeng, Z Kanji, B Ford… - Journal of medical …, 2020 - Wiley Online Library
Background Current evidence suggests an important role of the interleukin‐6 (IL‐6) pathway
in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐related cytokine …

Tocilizumab for the treatment of severe coronavirus disease 2019

R Alattar, TBH Ibrahim, SH Shaar… - Journal of medical …, 2020 - Wiley Online Library
Abstract Tocilizumab, an interleukin‐6 inhibitor, may ameliorate the inflammatory
manifestations associated with severe coronavirus disease 2019 (COVID‐19) and thus …

Impact of low dose tocilizumab on mortality rate in patients with COVID-19 related pneumonia

R Capra, N De Rossi, F Mattioli, G Romanelli… - European journal of …, 2020 - Elsevier
Background Pneumonia with respiratory failure represents the main cause of death in
COVID-19, where hyper inflammation plays an important role in lung damage. This study …

Tocilizumab in hospitalized patients with COVID‐19: clinical outcomes, inflammatory marker kinetics, and safety

JA Hill, MP Menon, S Dhanireddy… - Journal of medical …, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) due to infection with severe acute
respiratory syndrome coronavirus 2 causes substantial morbidity. Tocilizumab, an …